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EC number: 208-932-1 | CAS number: 547-66-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A Local Lymphe Node Assay (LLNA, OECD 429) was conducted on oxalic acid. It is considered as a relevant study for magnesium oxalate in a read across approach. Considering the result of this study, magnesium oxalate has not to be considered as dermal sensitiser.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Further information in a detailed justification report is included as attachment to the same record.
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
For the determination of analogue in this read-across approach, the following points have been considered:
- Chemical speciation and valency (common magnesium cation: Mg2+).
- The water solubility, as it provides a first indication of the availability of the metal ion in the different compartments of interest. The most simplistic approach to hazard evaluation is to assume that the specific metal-containing compound to be evaluated shows the same hazards as the most water-soluble compounds.
- In fluids of organisms and in aqueous media, dissociation of magnesium oxalate takes place immediately, resulting in formation of magnesium cations (Mg2+) and oxalate anions. Thus, any ingestion or absorption of magnesium oxalate by living organisms, in case of systemic consideration, will inevitably result of exposure to the dissociation products.
- Magnesium is an abundant mineral naturally present in the body. It is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation (IOM 1997, Rude 2010, Rude 2012). Magnesium is required for the normal functioning of several biochemical and physiological reactions and pay an essential role in the human body (Rude 2012). An adult body contains approximately 25 g magnesium, with 50% to 60% present in the bones and most of the rest in soft tissues (Volpe 2012). Human Recommended Dietary Allowances (RDA) for magnesium is up to 420mg per day (IOM 1997). For the same reasons (involvement in biochemical and physiological functions), magnesium is also naturally present in various organisms of the environment such as fish, crustacea or vegetables. Besides they are identified as food sources of magnesium (US 2012). Consequently, it can be concluded that magnesium is of low (eco)toxicological relevance when ingested and taken up systemically. Thus, any possible toxicological or ecotoxicological effect triggered by magnesium oxalate exposure can be attributed to oxalate anion.
- Counter ions: the assumption that the oxalate ion is responsible for the common property or effect implies that the toxicity or ecotoxicity of the counter ion present in the compound will be largely irrelevant in producing the effects to be assessed.
- Likely common breakdown products via physical and/or biological processes for the targeted substance (magnesium oxalate) and the analogues identified cannot present strong differences since the structures are very simple and very similar (formation of Mg2+ or oxalate ion).
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Source chemical information is provided in the “source” endpoint. No impurity affecting the classification is reported for the source chemical.
Information on the impurities of the target chemical are detailed in the attached report.
3. ANALOGUE APPROACH JUSTIFICATION
The main hypothesis for the analogue approach are verified. They are presented in the detailed report attached. The experimental data performed on the substance (tests performed in this REACH registration dossier on strontium peroxide) confirms the analogue approach performed (same results on analogues).
4. DATA MATRIX
A data matrix is presented in the detailed report attached. - Reason / purpose for cross-reference:
- read-across source
- Parameter:
- SI
- Remarks on result:
- other: see Remark
- Remarks:
- None of the 3 concentrations tested reached the stimulation index of 3: The stimulation index at a concentration of 12.5% was of 2.6 The stimulation index at a concentration of 25% was of 1.9 The stimulation index at a concentration of 50% was of 2.5
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- The EC3 value (derived by linear interpolation) could not be calculated as the stimulation indices of all concentrations were below 3.
Consequently, according to OECD 429 and the criteria given in Annex I of Regulation (EC) 1272/2008, the test item Oxalic Acid, as described in this report is expected to have no sensitising properties and therefore, should not be regarded as a dermal sensitiser. This result is relevant in a read across approach and is used for assessing magnesium oxalate properties. Consequently, in a read across approach, magnesium oxalate is not to be considered as skin sensitiser.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
Since the stimulation indices of all tested concentrations were below 3 in the LLNA assay, no classification is needed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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