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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 December 2017 - 30 May 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Key result
Water solubility:
1.52 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
7
Details on results:
The water solubility of the test item was determined to be 1.52 ± 0.03 g/L at 20°C

Table 1: Standard Calibration for the test item

 Standard concentration (mg/L)  Peak area
 5680  417.77
 4611  329.37
 3009  224.25
 1935  139.06
 945.1  65.527
 522.3  47.907

Linear regression: y = 0.07219x - 3.022, r = 0.9992

Table 2: Summary of Water Solubility Results

Days at 30 °C

Sample 

 Concentration (g/L)

 pH

 1

 1 A

 1.57

 5.8

 

 1 B

 1.51

 5.9

 2

 2 A

 1.50

 5.9

 

 2 B

 1.52

 5.9

 3

 3 A

 1.49

 5.9

 

 3 B

 1.54

 5.9

Mean = 1.52 g/L

Standard Deviation = 0.03 g/L

RSD = 1.9 %

Table 3: Water Solubility

Sample   Peak area  Concentration CA (mg/L)  Dilution Factor  Concentration CB (mg/L)
 3079 mg/L std  242.89  -  -  -
 Sample 3 A  118.29  1494  1  1.494
 Sample 3 B  121.85  1539  1  1.539
 Sample 2 A  118.50  1497  1  1.497
 Sample 2 B  120.44  1522  1  1.522
 3079 mg/L std  244.53  -  -  -
 Sample 1 A  125.39  15873  1  1.573
 Sample 1 B  120.39  1510  1  1.510
 3079 mg/L std  246.41  -  -  -
Conclusions:
The water solubility of the test item was determined to be 1.52 ± 0.03 g/L at 20°C.
Executive summary:

The water solubility of the test item was determined in a study following OECD 105 and EC Method A6 guidelines, using the flask method. The water solubility of the test item was determined to be 1.52 ± 0.03 g/L at 20 °C.

The study is a GLP compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.

Description of key information

The water solubility of the test item was determined to be 1.52 ± 0.03 g/L at 20°C.

Key value for chemical safety assessment

Water solubility:
1.52 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test item was determined in a study following OECD 105 and EC Method A.6 guidelines, using the flask method (Dunning 2018). The water solubility of the test item was determined to be 1.52 ± 0.03 g/L at 20°C.

 

The study is a GLP-compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.