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EC number: 256-917-3 | CAS number: 51022-74-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-01-25 to 2018-05-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- 304 mg/L
- Temp.:
- 20 °C
- pH:
- 3.3
- Conclusions:
- The water solubility of the test item was 304 mg/l (± 21 mg/l) and the saturated solutions had a pH of 3.3.
- Executive summary:
The water solubility of the test item was determined according to EC method A.6. and OECD test guideline 105 using the flask method and HPLC as analytical method. The water solubility of the test item was found to be 304 mg/l (± 21 mg/l) and the saturated solutions had a pH of 3.3.
Reference
Preliminary test
In a stepwise procedure, increasing volumes of demineralized water were added at room temperature to a defined amount of the test item. After each addition of an amount of water the mixture was treated with ultrasound for 10 minutes and visually checked for any undissolved particles. Table 1 summarizes results of the preliminary test.
Table 1: Results of the preliminary test
Amount of test item / mg |
Added volume of demineralized water / ml |
Total volume of demineralized water / ml |
Appearance of mixture |
100.4 |
0.1 |
0.1 |
Slurry-like dispersion |
0.4 |
0.5 |
Strongly turbid solution with precipitate |
|
0.5 |
1.0 |
Strongly turbid solution with precipitate |
|
1.0 |
2.0 |
Strongly turbid solution with precipitate |
|
8.0 |
10.0 |
Turbid solution |
Three additional preliminary tests were carried out with specified amounts of the test item and 100 ml, 500 ml and 1000 ml demineralized water, respectively. After each addition of an amount of water, the mixture was stirred for at least 24 hours, and visually checked for any undissolved particles. The results of those tests are shown in Table 2.
Table 2: Results of the preliminary test
Amount of test item / mg |
Total volume of demineralized water / ml |
Appearance of mixture |
12.8 |
100 |
Solution with little particles |
8.5 |
500 |
Solution with little particles |
9.0 |
1000 |
Solution with little particles |
The preliminary test showed that the water solubility of the test item was < 10 mg/l. According to the preliminary test the water solubility was first determined by the column elution method in the main test. The water solubility determined by the column elution method was > 10 mg/l. Therefore, the study was repeated with the flask method.
Flask method
After the equilibration time precipitate was observed in the flasks of the experiments excluding the ones in the blank experiment. The water solubility was calculated from the measured and unrounded concentration values and not from the rounded values given in Table 3.
Table 3: Results of the water solubility experiments with the test item
Experiment |
24 h experiment |
48 h experiment |
72 h experiment |
Blank experiment (72 h) |
Amount of test item / g |
5.01 |
5.00 |
5.02 |
- |
Amount of demineralized water / ml |
50 |
50 |
50 |
50 |
Stirring time at 30 °C / h |
24 |
48 |
72 |
72 |
pH at ambient temperature |
3.3 |
3.3 |
3.3 |
5.7 |
Dilution factor |
40 |
40 |
40 |
40 |
Measured concentration / mg/l |
6.99 / 7.01 |
7.93 / 7.95 |
7.82 / 7.85 |
- / - |
Mean concentration / mg/l |
7.00 |
7.94 |
7.84 |
- |
Water solubility / mg/l |
280 |
318 |
314 |
- |
Description of key information
The water solubility of the test item was determined according to EC method A.6. and OECD test guideline 105 using the flask method and HPLC as analytical method. The water solubility of the test item was found to be 304 mg/l (± 21 mg/l) and the saturated solutions had a pH of 3.3.
Key value for chemical safety assessment
- Water solubility:
- 304 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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