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EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- - Principle of test: The test material was administered as a single dose by oral gavage to 10 animals/dose. Examinations: Clinical observations at 0-6 hr after dosing and daily thereafter for 14 days. Body weights at 0 and 14 days. Necropsy on found dead and on survivors at day 14.
- Short description of test conditions: Single dose, 10 animals/dose, post-examination up to 14 days
- Parameters analysed / observed: Mortality, and clinical observations, body weights and necropsy - GLP compliance:
- no
- Remarks:
- The study was conducted in 1977 before implementation of the GLP. However, it follows the scientific procedures in force at that time, is well documented and raw data is available.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- other: Amber liquid
- Details on test material:
- - Name of test material (as cited in study report): Kathon™ 886 all magnesium formulation
- Physical state: Amber liquid
- Stability under test conditions: stable at room temperature
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. 76/0445 and 0098
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: Stable
- Solubility and stability of the test substance in the solvent/vehicle: Soluble and stable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: Dilution in water
- Final dilution of a dissolved solid, stock liquid or gel: 221, 313, 442, 625 or 883 mg/kg bw
OTHER SPECIFICS: Purity of test material was 14 % a.i. (Batch No. 76/0445) and 13.3 % a.i. (Batch No. 0098)
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Age at study initiation: Adult
- Weight at study initiation: 209 to 211 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Kathon™ 886 was prepared as a 10 % w/v aqueous dispersion - Doses:
- 221, 313, 442, 625 or 883 mg/kg b.w.
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations at 0-6 hr after dosing and daily thereafter for 14 days. Body weights at 0 and 14 days. Necropsy on found dead and on survivors at day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 457 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 382 - <= 580
- Remarks on result:
- other: Lot 76/0445
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 64 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: Lot 76/0445
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 561 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 482 - <= 654
- Remarks on result:
- other: Lot 0098
- Mortality:
- Lot 76/0445: The acute oral LD50 in male rats was 457 mg/kg with 95 % confidence limits of 382 and 580 mg/kg, whole product.
Lot 0098: The acute oral LD50 in male rats was 561 mg/kg with 95 % confidence limits of 482 and 654 mg/kg, whole product. - Clinical signs:
- other: Clinical signs were observed in all dose levels of this study. Lot 76/0445: salivation, lethargy, ptosis, piloerection, lacrimation, ataxia, prostration, nasal discharge and diarrhea. Lot 0098: lethargy, ptosis, piloerection, lacrimation, ataxia, prostrat
- Gross pathology:
- Necropsy of the decedents and survivors revealed gross changes in all dose levels.
Lot 76/0445: decedents - reddening and irritation of the stomach and intestines and sloughing of the stomach mucosa; survivors – scar tissue of the stomach and reddening of the intestines.
Lot 0098: decedents - reddened intestines, reddening and edema of the stomach, sloughing of the stomach mucosa and gas distention of the intestines; survivors scar tissue of the stomach and reddening of the stomach and intestines.
Any other information on results incl. tables
Table A6.1.1/01-1. Table for Acute Oral Toxicity in Rats |
||||||
Dose (mg/kg) |
Number of dead / Lot 76/0445 Lot 0098 |
Time of death (range) Lot 76/0445 Lot 0098 |
Observations |
|||
221 |
1/10 |
0/10 |
day 6 |
no deaths |
|
|
313 |
0/10 |
0/10 |
no deaths |
no deaths |
|
|
442 |
4/10 |
2/10 |
4 at 0-6 h |
2 at 0-6 h |
|
|
625 |
9/10 |
6/10 |
9 at 0-6 h |
4 at 0-6 h; 1 at 24h ; 1 at 8-14 days |
|
|
883 |
no animals dosed |
10/10 |
no animals |
8 at 0-6 h; 2 at 24h |
|
|
LD50value |
457 mg/kg in male rats
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral LD50 in male rats is based on the lowest value, 457 mg/kg [64 mg/kg a.i.].
- Executive summary:
10 male rats per dose (221, 313, 442, 625 or 883 mg/kg b.w.) were tested. Clinical signs were observed in all dose levels of this study.
Lot 76/0445: salivation, lethargy, ptosis, piloerection, lacrimation, ataxia, prostration, nasal discharge and diarrhea.
Lot 0098: lethargy, ptosis, piloerection, lacrimation, ataxia, prostration, nasal discharge and diarrhea.
The acute oral LD50in male rats is based on the lowest value, 457 mg/kg Kathon 886 corresponding to 64 mg/kg a.i. (pure CMIT/MIT).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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