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EC number: 249-636-2 | CAS number: 29450-45-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03.09.2008 - 17.09.2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-ethylhexyl (4-chloro-2-methylphenoxy)acetate
- EC Number:
- 249-636-2
- EC Name:
- 2-ethylhexyl (4-chloro-2-methylphenoxy)acetate
- Cas Number:
- 29450-45-1
- Molecular formula:
- C17H25ClO3
- IUPAC Name:
- 2-ethylhexyl (4-chloro-2-methylphenoxy)acetate
- Reference substance name:
- (4-chloro-2-methylphenoxy)acetic acid
- EC Number:
- 202-360-6
- EC Name:
- (4-chloro-2-methylphenoxy)acetic acid
- Cas Number:
- 94-74-6
- Molecular formula:
- C9H9ClO3
- IUPAC Name:
- (4-chloro-2-methylphenoxy)acetic acid
- Test material form:
- liquid
Constituent 1
impurity 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Wistar rats (outbred) used in experiment came from conventional culture of Institute of Occupational Medicine, Łódź.
Prior to the start of dosing, the animals were quarantined and observed daily for at least 5 days. The general medical-veterinary examination was performed on day of introduction of animals to quarantine. Detailed medical veterinary examination was performed prior to the beginning of experiment. Animals without any clinical signs were introduced to the experiment. All animals were individually marked.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- The test item was administered to females once in form of emulsion in corn-oil with the aid of ball ended feeding needle affixed to the top of syringe in volume 0.5 mL of emulsion per 100 g of rat body weight. 1 ml of administered emulsion contained 60 mg of test item (dose 300 mg/kg b.w.).
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - <= 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
Clinical signs
Following administration of test item in dose 300 mg/kg b.w. to one rat female in the sighting study, the following signs of toxicity were stated:
· wavering gait – from 3rdhour after administration to 2nd day of observation;
· paresis of hind limbs – from 4thhour after administration of test item to 1st day of observation;
· vocalization (animal squeezed during catching) – from 5th hour after administration to 1stday of observation;
· slight decrease in locomotor activity on 2ndday of observation.
The female survived 14-day period of observation.
Following administration of test item in dose 300 mg/kg b.w. to next four rat females in the main study, the following signs of toxicity were stated in all females:
· wavering gait from 1st to 5th hour after administration (females No 2, No 3 and No 4) and to 1st day of observation (female No 5);
· paresis of hind limbs – during 4th and 5thhour after administration of test item;
· slight decrease in locomotor activity – during 2ndhour after administration of test item and on 1stday of observation; distinct decrease in locomotor activity – from 3rdto 5thhour after administration of test item; dejection – from 4thto 5thhour after administration of test item.
All females survived 14-day period of observation.
Post mortem examination
At necropsy left-handed swelling and fragility of liver was stated in female No 1, what could be connected with individual sensitivity of this female to test item. No pathological changes were stated in the remaining rats.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Executive summary:
On the ground of the study one may state, that MCPA-2EH may be classified to category 4 – according to the Globally Harmonized System (GHS).
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