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Diss Factsheets
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EC number: 204-198-1 | CAS number: 117-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- non information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
Test material
- Reference substance name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- EC Number:
- 204-198-1
- EC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
- Cas Number:
- 117-57-7
- Molecular formula:
- C11H9NO3
- IUPAC Name:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 50 mg - Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- 1 hour, 24 hours, 8 days after application
Results and discussion
In vivo
Results
- Remarks on result:
- other:
- Remarks:
- slight irritation observed up to 24 hours after application; fully reversible within 8 days
- Irritant / corrosive response data:
- 1 hour after application: slight redness in mucous membrane, slight edema and pastel green substance remnants; 24 hours after application: slight redness in mucous membrane; 8 days after application: no effects observed (former effects fully reversed). The same effects profile was obtained with talcum.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, 3-hydroxy-2-methylquinoline-4-carboxylic acid was not irritating to the eyes.
- Executive summary:
In a primary eye irritation study, 3-hydroxy-2-methylquinoline-4-carboxylic acid was applied to the eye in rabbits. Animals then were observed for 8 days. Slight irritating effects were observed 1 hour after application by observation of slight conjunctival redness, slight edema and pastel green substance remnants. 24 hours after application, slight conjunctival redness was still observed. 8 days after application, no effects were observed (former effects fully reversed). The same effects profile was obtained with talcum.
In this study, 3-hydroxy-2-methylquinoline-4-carboxylic acid is not an eye irritant.
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