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Diss Factsheets
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EC number: 204-198-1 | CAS number: 117-57-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
-skin irritation: RL4; pre-GLP; rabbit; observation time: 8 days; only yellow substance remnant was observed in animals with 20h dorsal treatment.
-eye irritation: RL4; pre-GLP; rabbit; observation time: 8 days; slight irritating effects (conjunctival redness) 1 hour after application, slight edema and pastel green substance remnants; slight conjunctival redness up to 24 h after application; all effects fully reversed after 8 days.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Principles of method if other than guideline:
- no information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- water
- Amount / concentration applied:
- TEST MATERIAL
- Concentration: 50% (aqueous grinding) - Duration of treatment / exposure:
- 20h (dorsal)
- Observation period:
- observation 24h and 8 days after treatment
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 3-hydroxy-2-methylquinoline-4-carboxylic acid was not irritating in the in vivo skin irritation test.
- Executive summary:
In a primary dermal irritation study rabbits were dermally exposed to 50% 3-hydroxy-2-methylquinoline-4-carboxylic acid (vehicle: water) for 20 hours (dorsal).
Animals were observed 24 hours as well as 8 days after application.
Only yellow substance remnant was observed in animals with 20h dorsal treatment.
In this study, 3-hydroxy-2-methylquinoline-4-carboxylic acid is not a dermal irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Principles of method if other than guideline:
- non information available
- GLP compliance:
- no
- Remarks:
- Study conducted prior to implementation of GLP
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 50 mg - Duration of treatment / exposure:
- not specified
- Observation period (in vivo):
- 1 hour, 24 hours, 8 days after application
- Remarks on result:
- other:
- Remarks:
- slight irritation observed up to 24 hours after application; fully reversible within 8 days
- Irritant / corrosive response data:
- 1 hour after application: slight redness in mucous membrane, slight edema and pastel green substance remnants; 24 hours after application: slight redness in mucous membrane; 8 days after application: no effects observed (former effects fully reversed). The same effects profile was obtained with talcum.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, 3-hydroxy-2-methylquinoline-4-carboxylic acid was not irritating to the eyes.
- Executive summary:
In a primary eye irritation study, 3-hydroxy-2-methylquinoline-4-carboxylic acid was applied to the eye in rabbits. Animals then were observed for 8 days. Slight irritating effects were observed 1 hour after application by observation of slight conjunctival redness, slight edema and pastel green substance remnants. 24 hours after application, slight conjunctival redness was still observed. 8 days after application, no effects were observed (former effects fully reversed). The same effects profile was obtained with talcum.
In this study, 3-hydroxy-2-methylquinoline-4-carboxylic acid is not an eye irritant.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Skin irritation
Based on available data, the test substance does not need to be classified for skin irritation according to regulation (EC) 1272/2008.
Eye irritation
Based on available data, the test substance does not need to be classified for eye irritation according to regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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