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Diss Factsheets
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EC number: 202-675-9 | CAS number: 98-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicological studies on p-tertiary-butyltoluene.
- Author:
- Hine CH et al.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch Ind Hyg Occup Med 9: 227-244.
- Reference Type:
- review article or handbook
- Title:
- p-tert-Butyoltoluol.
- Author:
- Greim H
- Year:
- 1 998
- Bibliographic source:
- Toxikologisch-arbeitsmedizinische Begründungen von MAK-Werten. Edited by Greim H. Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe der Deutschen Forschungsgemeinschaft (DFG), 26. Lieferung. Wiley-VCH-Verlagsgesellschaft, Weinheim.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4-tert-butyltoluene
- EC Number:
- 202-675-9
- EC Name:
- 4-tert-butyltoluene
- Cas Number:
- 98-51-1
- Molecular formula:
- C11H16
- IUPAC Name:
- 1-tert-butyl-4-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): p-tertiary-butyltoluene
- Physical state: liquid with distinct odour
- Analytical purity: no data
No further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
female Long-Evans rats
- Weight at study initiation: 110-156 g
- Fasting period before study: yes, 8 h prior to treatment
No further data.
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Animals were exposed either in a 165 liter chamber to a constant flow of 14.6 liters per minute (about five air changes per hour) or in a chamber of about 200 liters capacity to an air flow of 21.2 liters per minute (six air changes per hour). A constant-metering device delivered TBT liquid in measured amounts to the evaporator, where it vaporized in the air entering the chamber. The air in the chamber was allowed to equilibrate to, theoretically, 95 to 99% of the desired concentration.
TEST ATMOSPHERE
Vapour samples were collected occasionally as a check on the nominal chamber concentration. Evacuated glass bulbs were used in procuring the samples. The bulb was attached to the sampling port, and air from the chamber was drawn through by suction at the rate of 3 liters per minute for five minutes. Five milliliters of isooctane was added to the bulb, which was then shaken for 10 minutes. The quantity of absorbed TBT was determined by ultraviolet spectrophotometry, as described in the section on Industrial Health Aspects (Section III).
No further data. - Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 26 weeks
- Frequency of treatment:
- 1, 2, 4, 7 hours/day on 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
ca. 0.15, 0.3 mg/l (25-30, 50-60 ppm)
Basis:
nominal conc.
- No. of animals per sex per dose:
- groups of 10 females
- Control animals:
- yes, concurrent no treatment
Results and discussion
Results of examinations
- Details on results:
- CLINICAL SIGNS AND MORTALITY
The majority of exposed animals did not display any evidence of substance-related damage or abnormal behaviour. One of three high dose rats exposed for 7 h/d died after the 42nd exposure; the remaining two rats displayed injury at the front and hind limbs. During the study, clinical symptoms were limited to slight irritation of the eyes and slightly elevated respiratory rate.
BODY WEIGHT AND WEIGHT GAIN
no data
CLINICAL LABORATORY INVESTIGATIONS
A depression of erythropoiesis was observed. Hemoglobin, erythrocyte count and leukocyte count was decreased in high dose animals after 5 weeks of exposure. However, significant changes of these parameters were also observed in control animals at the beginning and end of the exposure period. Therefore, the authors did not consider the depression of erythropoiesis to be substance-related. No statistically significant changes in blood parameters were noted after 26 weeks of exposure, with exception of significantly decreased leukocyte counts observed in high dose rats treated for 2, 4, or 7 h/d.
ORGAN WEIGHTS
A time- and dose-related increase in relative liver and kidney weights was observed.
GROSS PATHOLOGY
no data
HISTOPATHOLOGY
Chronic encephalomeningitis was observed in both low and high dose rats exposed for 4 and 7 h. Slight fatty degeneration of the liver was noted in individual high dose rats.
No further data.
Effect levels
open allclose all
- Dose descriptor:
- NOAEC
- Effect level:
- < 0.15 mg/L air
- Sex:
- female
- Basis for effect level:
- other: According to a reviewer (Greim, 1998 = MAK-Begründung), a NOEL could not be established, based on adverse findings observed at both dose levels.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEC identified
- Dose descriptor:
- LOAEC
- Effect level:
- 0.15 mg/L air
- Sex:
- female
- Basis for effect level:
- other: According to a reviewer (Greim, 1998 = MAK-Begründung), a NOEL could not be established, based on adverse findings observed at both dose levels.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.