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EC number: 202-675-9 | CAS number: 98-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological studies on p-tertiary-butyltoluene.
- Author:
- Hine CH et al.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch Ind Hyg Occup Med 9: 227-244.
Materials and methods
- Principles of method if other than guideline:
- The study was carried out according to the following references:
- Hine CH et al (1953). Toxicology and Safe Handling of CBP-55 (Technical 1-Chloro-3-Bromopropene-1). AMA Arch Ind Hyg 7: 118-136.
- Draize J et al (1944). Methods for the Study of Irritation and Toxicity of Substances Applied Topically to the Skin and Mucous Membranes. J Pharm Exp Ther 82: 377-390. - GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-tert-butyltoluene
- EC Number:
- 202-675-9
- EC Name:
- 4-tert-butyltoluene
- Cas Number:
- 98-51-1
- Molecular formula:
- C11H16
- IUPAC Name:
- 1-tert-butyl-4-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): p-tertiary-butyltoluene
- Physical state: liquid with distinct odour
- Analytical purity: no data
No further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no further data on animals and environmental conditions
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No further details given.
- Duration of exposure:
- no further data
- Doses:
- ca. 9210, 13350, 19630 mg/kg bw (Original value: up to 10.7, 15.5, 22.8 ml/kg bw)
- No. of animals per sex per dose:
- totally 20 animals; see freetext
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 or 14 days; not exactly defined
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs for all animals. RBC, WBC, Hb, gross pathology and histopathology of decedents.
The rabbits were removed from the holder after 24 hours and examined for local and general effects. Moribund animals were killed for necropsy; blood was drawn for red and white cell counts and hemoglobin estimation, and suitable tissues were taken for histologic examination. - Statistics:
- LD50 was calculated by the method of Thompson WR (1947). Use of Moving Averages and Interpolation to Estimate Median-Effective dose. Bact Rev 11: 115-145.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 16 880 mg/kg bw
- 95% CL:
- 11 880 - 23 940
- Remarks on result:
- other: Original value: LD50 = 19.6 (13.8 - 27.8) ml/kg bw; density: 0.861 g/ml
- Mortality:
- None of totally 12 rabbits given up to 10.7 ml/kg bw died. Five of totally 8 animals given 15.5 or 22.8 ml/kg bw died.
No further data. - Clinical signs:
- other: None of the 12 rabbits receiving up to 10.7 ml/kg bw showed evidence of intoxication, but at 15.5 and 22.8 ml/kg bw, five of totally eight animals showed evidence of severe alterations in physiology and subsequently died. The survivors showed only minima
- Gross pathology:
- The results of gross pathology are described in a generalized manner.
Gross changes included marked liver damage and some evidence of irritation of the pulmonary tract. Gross lesions were present in the majority of animals which showed intoxication and survived for 10 or more hours and were invariably present in moribund animals which survived for 24 hours. These lesions consisted of cerebral edema, engorgement of the abdominal viscera, and enlargement and marked yellowish discoloration of the liver. - Other findings:
- - Histopathology:
The results of microscopic examination are presented for a battery of studies conducted with several species (rat, mouse and rabbit) and several routes of administration (oral, by inhalation, and dermal) and are presented here as a quotation.
“Microscopic examination of the tissues confirmed the extent of visceral involvement and disclosed a number of lesions in the central nervous system. The changes in the liver were principally due to fatty infiltration, which was either centrilobular or diffuse. In the tubular epithelium of the kidneys there were fine granular changes and moderate fatty deposits at the base. Pulmonary emphysema was conspicuous, and in some animals there was diffuse pulmonary edema and severe hemorrhage. All organs were hyperemic.
The lesions of the central nervous system […] may be summarized as follows: In cerebrum, cerebellum, and cord, there was diffuse edema of the white matter and occasionally acute necrosis, particularly in the corpus callosum and the cord. In many areas large vacuoles had formed which contained palely staining material of colloid-like appearance. Acute neuronal changes were present-swelling, vacuolation, and chromatolysis in the cortex, hippocampus, and cerebellum. In the spinal cord, beginning in the medulla oblongata, the nerve cells in the anterior gray columns frequently showed vacuolar changes of nuclei and occasionally complete chromatolysis. No lesions were seen in the sciatic nerves."
Applicant's summary and conclusion
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