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EC number: 257-297-7 | CAS number: 51581-32-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-02-13 to 2002-02-21
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-pyridyl dimethylcarbamate
- EC Number:
- 257-297-7
- EC Name:
- 3-pyridyl dimethylcarbamate
- Cas Number:
- 51581-32-9
- Molecular formula:
- C8H10N2O2
- IUPAC Name:
- pyridin-3-yl N,N-dimethylcarbamate
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- test materials was dissolved in deionised water (Millipore ELIX 10), pH was brought to 7.8+/- 0.2 via NaOH or H2SO4
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORAGNISMS
- Species: Daphnia magna STRAUS (HFA-strain C1)
- Age at study initiation: 1 - 24 h
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 24 h
Test conditions
- Test temperature:
- 20 +/- 2 °C
- pH:
- 7.8 +/- 0.2
- Dissolved oxygen:
- -
- Salinity:
- -
- Conductivity:
- -
- Nominal and measured concentrations:
- see Table 1 in 'Any other information on materials and methods incl. tables'
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- >= 93 - <= 116 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Any other information on results incl. tables
Table 2: Test evaluation Daphina toxicity
|
EC50, mL/L |
EC50-range, mg/L |
|||
|
|
< 1 |
1 - 10 |
10 – 100 |
> 100 |
Pyridobase |
~0.09 (0.08 – 0.1) |
|
|
|
X |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 value of pyridobase to Daphnia magna was found to be 93 - 116 mg/L (24 h).
- Executive summary:
The 24h acute toxicity of pyridobase to Daphnia magna was studied under static conditions according to ISO 6341. Daphnids were exposed to the test chemical at nominal concentrations of 0, 0.1, 1, 10, 20, 40, 50, 60, 80, 100, 1000 mg/L for 24 hr. Mortality/immobilisation and sub-lethal effects were observed at the end of the study period. The 24 -hour EC50 was 93 to 116 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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