Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 635-476-4 | CAS number: 88349-88-6
Endpoint summary
Administrative data
Description of key information
Cloquintocet acid did not demonstrate skin sensitisation potential in the local lymph node assay (LLNA). There is no evidence from experience of use that the substance has the potential to cause skin sensitisation in exposed workers.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A local lymph node assay (LLNA) was conducted to evaluate the skin sensitisation potential of cloquintocet acid in compliance with OECD test guideline 429 (Verma, 2013c). Stimulation indices for the 10%, 25% and 50% (w/v) treated groups were 0.91, 0.93 and 0.51, respectively. The SI obtained at all tested concentrations showed a less than three-fold increase over the control value; therefore, cloquintocet acid did not demonstrate dermal sensitisation potential under the conditions of the study.
There is no evidence from experience of use that cloquintocet acid has the potential to cause skin sensitisation in exposed workers.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
No animal data are available. There is no indication from the experience of use that the substance causes respiratory sensitisation in exposed workers.
Justification for classification or non-classification
Based on available information, cloquintocet acid does not meet the criteria for classification as a skin or respiratory sensitiser according to the CLP Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
