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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 635-476-4 | CAS number: 88349-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 7 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 25
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 175.9 mg/m³
- Explanation for the modification of the dose descriptor starting point:
In the absence of a repeated dose inhalation study, a corrected inhalation starting point (NOAEC) is derived from the oral repeated dose (90 -day) dietary study in the rat. Inhalation absorption is assumed to be 100%, oral absorption is 86% (determined experimentally). The NOAEL of 116 mg/kg bw/d obtained in the oral rat study is corrected for oral and inhalation absorption (86%/100%), standard respiratory volume for the rat (0.38 m³/kg/d, 8 h exposure) and respiratory volume of the worker assuming light activity (6.7 m³/10 m³, 8 h exposure):
Corrected inhalation NOAEC = oral NOAEL * oral absorption / rat respiratory volume * worker respiratory volume
= 116 mg/kg bw/d * (86%/100%) / 0.38 m³/kg/d * (6.7 m³/10 m³)
= 175.9 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Default value: starting point is NOAEL/NOAEC
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from sub-chronic study to chronic exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The application of a factor for allometric scaling is not required when the starting point is a NOAEC (allometric scaling is already taken into account when deriving the corrected starting point from the NOAEL).
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor
- AF for intraspecies differences:
- 5
- Justification:
- Default factor (workers)
- AF for the quality of the whole database:
- 1
- Justification:
- Default factor
- AF for remaining uncertainties:
- 1
- Justification:
- Default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.16 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 100
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 116 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
In the absence of a repeated dose dermal toxicity study, a corrected dermal starting point is derived from the oral repeated dose (90 -day) dietary study in the rat. The NOAEL of 116 mg/kg bw/d is corrected for oral and dermal absorption. Oral absorption is 86%; no suitable dermal absorption data are available therefore dermal absorption is assumed to be the same as oral absorption according to the ECHA REACH guidance.
Corrected dermal NOAEL = oral NOAEL * (oral absorption %/dermal absorption %)
= 116 mg/kg bw/d * (86%/86%)
= 116 mg/kg bw/d
- AF for dose response relationship:
- 1
- Justification:
- Starting point is NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from sub-chronic study to chronic exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Starting point is derived from a study in the rat
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor
- AF for intraspecies differences:
- 5
- Justification:
- Default factor (workers)
- AF for the quality of the whole database:
- 1
- Justification:
- Default factor
- AF for remaining uncertainties:
- 1
- Justification:
- Default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Toxicokinetics
The oral and dermal absorption, toxicokinetics and metabolism of cloquintocet acid can be adequately characterised based on the available experimental data.
Cloquintocet acid is rapidly and extensively absorbed following oral exposure and is likely to be rapidly and extensively absorbed following inhalation exposure. Oral absorption was determined to be 86%. Absorption following dermal exposure to a formulated plant protection product and in-use spray dilutions containing cloquintocet acid was found to be minimal, and reached the plateau of absorption by the 24 hour point with the remainder of the substance becoming not absorbable.
Cloquintocet acid is not widely distributed and is only slightly metabolised. Unchanged cloquintocet acid is rapidly and extensively excreted mainly in the urine but also in the faeces, indicating bioaccumulation is unlikely.
Acute toxicity
Cloquintocet acid was demonstrated to be of low acute toxicity: the acute oral LD50 was > 2000 mg/kg bw; the acute dermal LD50 was > 5000 mg/kg bw; and the acute inhalation 4 hour LC50 was > 6.11 mg/L.
Irritation/corrosion
Cloquintocet acid caused slight irritation to rabbit skin and eyes in in vivo guideline studies, however effects were fully reversible and not sufficient to trigger classification.
Skin sensitisation
No evidence of skin sensitisation was seen in a local lymph node assay with cloquintocet acid.
Repeated dose toxicity
In a 90-day repeated dose dietary toxicity study in rats (OECD 408) the NOAEL was the highest dose tested, 2100 ppm, which corresponded to time-weighted average concentrations of 116.0 and 127.0 mg/kg bw/day in males and females, respectively. On this basis, low toxicity is also predicted for the inhalation and dermal routes of exposure. The repeated dose toxicity of the substance is adequately elucidated by the oral route. Further testing via the dermal and inhalation routes is not required.
Genetic toxicity
No evidence of mutagenicity was seen in a bacterial reverse mutation assay (Ames test). In studies in mammalian cells in vitro, cloquintocet acid did not induce chromosomal aberrations when tested in human peripheral blood lymphocytes and was not clastogenic when tested in Chinese hamster ovary cells in either the absence or the presence of metabolic activation.
Toxicity to reproduction
No reproductive or developmental effects were observed in a dietary reproduction/developmental toxicity screening test (OECD 421) at the highest dose tested (2100 ppm, equivalent to 123 mg/kg/day for males and 125 mg/kg/day for females during pre-breeding and 143 mg/kg/day for females during the gestation and 227 mg/kg/day for females during lactation). The substance is not therefore predicted to be a reproductive toxicant.
No study of developmental toxicity is available; however a study is not considered necessary because no adverse effects on reproductive organs or tissues were reported in the 90-day repeat dose oral toxicity study and no relevant effects were seen in the reproductive/developmental toxicity screening study. The findings from the 90-day repeated dose oral toxicity study and the reproductive/developmental toxicity screening test provide an adequate characterisation of the reproductive toxicity hazard of the substance.
DNEL derivation [Workers]
The relevant (lowest) NOAEL for general/systemic toxicity used for DNEL derivation is 116 mg/kg bw/day, obtained from a 90-day repeated dose oral (dietary) study in rats.
Local effects
DNEL values for local effects are not derived. The substance is not a skin or eye irritant or a skin sensitiser. DNELs for local effects are therefore not proposed as no hazard is identified.
Systemic effects
The substance is of low systemic toxicity and has a low vapour pressure. No acute toxicity hazard resulting in classification has been identified, therefore DNELs for acute systemic effects are not proposed as no hazard is identified. The relevant NOAEL for general/systemic toxicity is used for derivation of long-term systemic DNELs.
[Dermal – long-term systemic DNEL]
As a repeated dose dermal toxicity study is not available, the long-term systemic dermal DNEL is derived from the oral repeated dose NOAEL using the route-to-route extrapolation approach and default assumptions given in the ECHA REACH guidance. The NOAEL of 116 mg/kg bw/d is corrected for oral and dermal absorption. Oral absorption is 86%; no suitable dermal absorption data are available therefore dermal absorption is assumed to be the same as oral absorption according to the ECHA REACH guidance. Dermal absorption data are available for cloquintocet acid from a formulated plant protection product and in-use spray dilutions, indicating that dermal absorption is expected to be very low (<2%). However, in the absence of a study conducted with the substance as such, the default assumption (dermal absorption = oral absorption) is made as a conservative worst-case approach.
The corrected dermal NOAEL is derived as follows: oral NOAEL x (% oral absorption/% dermal absorption) = 116 mg/kg bw/day x (86%/86%) = 116 mg/kg bw/day.
The use of assessment factors according to ECHA REACH guidance is considered below:
Intraspecies: default factors of 4 (allometric scaling: rat) and 2.5 (remaining differences)
Interspecies: a default factor of 5 for workers.
Exposure duration: a default factor of 2 for extrapolation from a sub-chronic study to chronic exposure. This represents a conservative approach, as the data indicate low toxicity following single and repeated exposures.
Dose-response: a default factor of 1 as the substance is of low toxicity
Quality of the data base: default factor of 1
An overall assessment factor of 100 for long-term dermal effects is therefore calculated for workers.
Applying the assessment factor of 100 to the corrected dermal NOAEL of 116 mg/kg bw/d gives a dermal DNEL of 1.16 mg/kg bw/d for long-term systemic effects.
[Inhalation – long-term systemic DNEL]
As a repeated dose inhalation toxicity study is not available, the long-term systemic inhalation DNEL is derived from the oral repeated dose NOAEL using the route-to-route extrapolation approach and default assumptions given in the ECHA REACH guidance. A corrected inhalation starting point (NOAEC) is derived from the NOAEL of 116 mg/kg bw/d; the NOAEL is corrected for oral and inhalation absorption (86%/100%), the respiratory volume for the rat (0.38 m³/kg/d, 8 h exposure) and respiratory volume of the worker assuming light activity (6.7 m³/10 m³, 8 h exposure).
The corrected inhalation NOAEC is derived as follows: oral NOAEL * oral absorption / rat respiratory volume * worker respiratory volume = 116 mg/kg bw/d * 86% / 0.38 m³/kg/d * (6.7 m³/10 m³) = 175.9 mg/m³
The use of assessment factors according to ECHA REACH guidance is considered below:
Intraspecies: a default factor of 2.5 (remaining differences; the application of a factor for allometric scaling is not required when the starting point is a NOAEC)
Interspecies: a default factor of 5 for workers.
Exposure duration: a default factor of 2 for extrapolation from a sub-chronic study to chronic exposure. This represents a conservative approach, as the data indicate low toxicity following single and repeated exposures.
Dose-response: a default factor of 1as the substance is of low toxicity
Quality of the data base: a default factor of 1
An overall assessment factor of 25 for long-term inhalational effects is therefore calculated for workers.
Applying the assessment factor of 25 to the corrected inhalation NOAEC of 175.9 mg/m³ gives an inhalation DNEL of 7.0 mg/m³ for long-term systemic effects.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.7 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 86.7 mg/m³
- Explanation for the modification of the dose descriptor starting point:
In the absence of a repeated dose inhalation study, a corrected inhalation starting point (NOAEC) is derived from the oral repeated dose (90 -day) dietary study in the rat. Inhalation absorption is assumed to be 100%. The NOAEL of 116 mg/kg bw/d obtained in the oral rat study is corrected for oral and inhalation absorption (86%/100%) and standard respiratory volume for the rat (1.15 m³/kg/d, 24 h exposure):
Corrected inhalation NOAEC = oral NOAEL * oral absorption / rat respiratory volume
= 116 mg/kg bw/d * (86%/100%) / 1.15 m³/kg/d
= 86.7 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Starting point is NOAEL/NOAEC
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from sub-chronic study to chronic exposure
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- The application of a factor for allometric scaling is not required when the starting point is a NOAEC (allometric scaling is already taken into account when deriving the corrected starting point from the NOAEL).
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor
- AF for intraspecies differences:
- 10
- Justification:
- Default factor (general population)
- AF for the quality of the whole database:
- 1
- Justification:
- Default factor
- AF for remaining uncertainties:
- 1
- Justification:
- Default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Explanation for the modification of the dose descriptor starting point:
The substance is of low systemic toxicity and has a low vapour pressure. No acute toxicity hazard resulting in classification has been identified, therefore a DNEL for acute systemic effects is not proposed. The long term DNEL is considered to be protective of any short term effects.
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.58 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 116 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
In the absence of a repeated dose dermal toxicity study, a corrected dermal starting point is derived from the oral repeated dose (90 -day) dietary study in the rat. The NOAEL of 116 mg/kg bw/d is corrected for oral and dermal absorption. Oral absorption is 86%; no suitable dermal absorption data are available therefore dermal absorption is assumed to be the same as oral absorption according to the ECHA REACH guidance.
Corrected dermal NOAEL = oral NOAEL * (oral absorption %/dermal absorption %)
= 116 mg/kg bw/d * (86%/86%)
= 116 mg/kg bw/d
- AF for dose response relationship:
- 1
- Justification:
- Starting point is NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from sub-chronic study to chronic exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Starting point is derived from a study in the rat
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor
- AF for intraspecies differences:
- 10
- Justification:
- Default factor (general population)
- AF for the quality of the whole database:
- 1
- Justification:
- Default factor
- AF for remaining uncertainties:
- 1
- Justification:
- Default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.58 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 200
- Dose descriptor starting point:
- NOAEL
- Value:
- 116 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
The starting point is a NOAEL from a repeated dose oral toxicity study, therefore modification is not required.
- AF for dose response relationship:
- 1
- Justification:
- Starting point is NOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- Extrapolation from sub-chronic study to chronic exposure
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- Starting point is derived from a study in the rat
- AF for other interspecies differences:
- 2.5
- Justification:
- Default factor
- AF for intraspecies differences:
- 10
- Justification:
- Default factor (general population)
- AF for the quality of the whole database:
- 1
- Justification:
- Default factor
- AF for remaining uncertainties:
- 1
- Justification:
- Default factor
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
DNEL derivation [General Population]
The relevant (lowest) NOAEL for general/systemic toxicity used for DNEL derivation is 116 mg/kg bw/day, obtained from a 90-day repeated dose oral (dietary) study in rats.
Local effects
DNEL values for local effects are not derived. The substance is not a skin or eye irritant or a skin sensitiser. DNELs for local effects are therefore not proposed as no hazard is identified.
Systemic effects
The substance is of low systemic toxicity and has a low vapour pressure. No acute toxicity hazard resulting in classification has been identified, therefore DNELs for acute systemic effects are not proposed as no hazard is identified. The relevant NOAEL for general/systemic toxicity is used for derivation of long-term systemic DNELs.
[Dermal – long-term systemic DNEL]
As a repeated dose dermal toxicity study is not available, the long-term systemic dermal DNEL is derived from the oral repeated dose NOAEL using the route-to-route extrapolation approach and default assumptions given in the ECHA REACH guidance. The NOAEL of 116 mg/kg bw/d is corrected for oral and dermal absorption. Oral absorption is 86%; no suitable dermal absorption data are available therefore dermal absorption is assumed to be the same as oral absorption according to the ECHA REACH guidance. Dermal absorption data are available for cloquintocet acid from a formulated plant protection product and in-use spray dilutions, indicating that dermal absorption is expected to be very low (<2%). However, in the absence of a study conducted with the substance as such, the default assumption (dermal absorption = oral absorption) is made as a conservative worst-case approach.
The corrected dermal NOAEL is derived as follows: oral NOAEL x (% oral absorption/% dermal absorption) = 116 mg/kg bw/day x (86%/86%) = 116 mg/kg bw/day.
The use of assessment factors according to ECHA REACH guidance is considered below:
Intraspecies: default factors of 4 (allometric scaling: rat) and 2.5 (remaining differences).
Interspecies: a default factor of 10 for the general population.
Exposure duration: a default factor of 2 for extrapolation from a sub-chronic study to chronic exposure. This represents a conservative approach, as the data indicate low toxicity following single and repeated exposures
Dose-response: a default factor of 1 is proposed as the substance is of low toxicity
Quality of the data base: default factor of 1
An overall assessment factor of 200 for long-term dermal effects is therefore calculated for the general population
Applying the assessment factor of 200 to the corrected dermal NOAEL of 116 mg/kg bw/d gives a dermal DNEL of 0.58 mg/kg bw/d for long-term systemic effects.
[Inhalation – long-term systemic DNEL]
As a repeated dose inhalation toxicity study is not available, the long-term systemic inhalation DNEL is derived from the oral repeated dose NOAEL using the route-to-route extrapolation approach and default assumptions given in the ECHA REACH guidance. A corrected inhalation starting point (NOAEC) is derived from the NOAEL of 116 mg/kg bw/d; the NOAEL is corrected for oral and inhalation absorption (86%/100%) and the standard respiratory volume for the rat (1.15 m³/kg/d, 24 h exposure).
The corrected inhalation NOAEC is derived as follows: oral NOAEL * oral absorption / rat respiratory volume = 116 mg/kg bw/d * 86% / 1.15 m³/kg/d = 86.7 mg/m³
The use of assessment factors according to ECHA REACH guidance is considered below:
Intraspecies: a default factor of 2.5 (remaining differences; the application of a factor for allometric scaling is not required when the starting point is a NOAEC)
Interspecies: a default factor of 10 for the general population
Exposure duration: a default factor of 2 for extrapolation from a sub-chronic study to chronic exposure. This represents a conservative approach, as the data indicate low toxicity following single and repeated exposures
Dose-response: a default value of 1 as the substance is of low toxicity
Quality of the data base: default factor of 1
An overall assessment factor of 50 for long-term inhalational effects is therefore calculated for the general population.
Applying the assessment factor of 50 to the corrected inhalation NOAEC of 86.7 mg/m³ gives an inhalation DNEL of 1.7 mg/m³ for long-term systemic effects.
[Oral – long-term systemic DNEL]
The NOAEL of 116 mg/kg bw/d obtained in the repeated dose oral toxicity study is used as the starting point; route-to-route extrapolation is not required.
The use of assessment factors according to ECHA REACH guidance is considered below:
Intraspecies: default factors of 4 (allometric scaling: rat) and 2.5 (remaining differences).
Interspecies: a default factor of 10 for the general population.
Exposure duration: a default factor of 2 for extrapolation from a sub-chronic study to chronic exposure. This represents a conservative approach, as the data indicate low toxicity following single and repeated exposures
Dose-response: a default factor of 1 is proposed as the substance is of low toxicity
Quality of the data base: default factor of 1
An overall assessment factor of 200 for long-term oral effects is therefore calculated for the general population
Applying the assessment factor of 200 to the oral NOAEL of 116 mg/kg bw/d gives an oral DNEL of 0.58 mg/kg bw/d for long-term systemic effects.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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