Registration Dossier
Registration Dossier
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EC number: 241-318-1 | CAS number: 17283-81-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-2-one
- EC Number:
- 241-318-1
- EC Name:
- 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-2-one
- Cas Number:
- 17283-81-7
- Molecular formula:
- C13H22O
- IUPAC Name:
- 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-2-one
- Reference substance name:
- rel-4-((1R,6R)-2,2,6-trimethylcyclohexyl)butan-2-one
- Cas Number:
- 60761-23-1
- Molecular formula:
- C13H24O
- IUPAC Name:
- rel-4-((1R,6R)-2,2,6-trimethylcyclohexyl)butan-2-one
- Test material form:
- liquid
Constituent 1
impurity 1
Test animals
- Species:
- rat
- Strain:
- other: HanIbm: WIST (SPF)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- No. of animals per sex per dose:
- 3 female or three male rats were used in each of the 2 groups
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured during the study
- Clinical signs:
- other: In two females, ruffled fur, hunched posture and sedation were observed on test day 2. In one female ruffled fur persisted until test day 3.
- Gross pathology:
- No macroscopic findings were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Executive summary:
LD50 in the rat for this study is greated than 2000 mg/kg body weight.
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