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Diss Factsheets
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EC number: - | CAS number: 75045-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature - cited from OECD SIDS and US EPA
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- Principles of method if other than guideline:
- In a combined, repeated-dose reproductive/developmental toxicity study, Sprague-Dawley rats (10/sex/dose) were administered the test substance orally in the diet at 1000, 2750 or 7500 ppm (ca. 50, 138 or 375 mg/kg bw/day). Treatment began 2 weeks prior to mating and continued throughout maturation, mating, gestation and up today 5 of lactation (ca. 47 days). The dose levels were reduced to 900, 2500 or 6750 ppm (ca. 45, 125 or 338 mg/kg bw/d) on day 29. On study day 33, the high dose group was further reduced to 5500 ppm (ca. 275 mg/kg bw/d) due to observed toxicity. A control group of similar size was given untreated diet only.
Following 2 weeks of dosing, male and female rats were paired within their dose groups to produce litters. At day 5 post partum, all surviving females and offspring together with all adult males were killed and examined macroscopically - GLP compliance:
- yes
Test material
- Reference substance name:
- 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt
- EC Number:
- 262-872-0
- EC Name:
- 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt
- Cas Number:
- 61617-00-3
- Molecular formula:
- C8H8N2S.1/2Zn
- IUPAC Name:
- Zinc bis[4(or 5)-methyl-2-thioxo-2,3-dihydrobenzimidazol-1-ide]
- Details on test material:
- methyl-2-mercaptobenzimidazole, zinc salt
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: diet
- Details on mating procedure:
- Following 2 weeks of dosing, male and female rats were paired within their dose groups to produce litters
- Duration of treatment / exposure:
- ca. 47 days
- Frequency of treatment:
- daily
- Duration of test:
- ca. 47 days
- No. of animals per sex per dose:
- 10/sex/dose
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
No significant clinical or macroscopic findings were noted; however the high incidence of mortality in the dams (9) and the limited number of viable offspring in the mid - and high-dose groups precluded meaningful evaluation, therefore effect levels for developmental toxicity could not be established.
Applicant's summary and conclusion
- Conclusions:
- Due to the high incidence of mortality in the dams and the limited number of viable offspring in the mid and high dose groups the results of the study are not qualified for assessment
- Executive summary:
In a combined, repeated-dose reproductive/developmental toxicity study, Sprague-Dawley rats (10/sex/dose) were administered the test substance orally in the diet at 1000, 2750 or 7500 ppm (ca. 50, 138 or 375 mg/kg bw/day). Treatment began 2 weeks prior to mating and continued throughout maturation, mating, gestation and up today 5 of lactation (ca. 47 days). The dose levels were reduced to 900, 2500 or 6750 ppm (ca. 45, 125 or 338 mg/kg bw/d) on day 29. On study day 33, the high dose group was further reduced to 5500 ppm (ca. 275 mg/kg bw/d) due to observed toxicity. A control group of similar size was given untreated diet only.
Following 2 weeks of dosing, male and female rats were paired within their dose groups to produce litters. At day 5 post partum, all surviving females and offspring together with all adult males were killed and examined macroscopically.
No significant clinical or macroscopic findings were noted; however the high incidence of mortality in the dams (9) and the limited number of viable offspring in the mid - and high-dose groups precluded meaningful evaluation, therefore effect levels for developmental toxicity could not be established.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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