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Diss Factsheets
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EC number: - | CAS number: 75045-07-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In 2 valid studies methyl-2mercaptobenzimidazole, zinc salt or methyl-2-mercaptobenzimidazole was tested for skin irritation/corrosion and eye irritation. The test substance was not irritating in both studies.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient documented and scientifically acceptable
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- 500 mg of the test substance were semi-occlusively applied once to the intact skin onto the inside of the ear of one male and one female young adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Evaluation of skin irritation was made until day 7 according to Draize et al. (J.Pharmacol. Exp. Ther. 82, 377-390 (1944).
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: application at the inside of the ear
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 7 days
- Number of animals:
- 2 animals
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- animal #1
- Time point:
- other: 1 h, 24 h, 4 d, 5 d, 6 d, 7 d
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not applicable - score = 0 at any time point
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- animal #2
- Time point:
- other: 1 h, 24 h, 2 d, 3 d, 6 d, 7 d
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not applicable - score = 0 at any time point
- Other effects:
- no data
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
- 500 mg of the test substance were semi-occlusively applied once to the intact skin onto the inside of the ear of one male and one female young adult New Zealand White rabbit(3-4 kg) for an exposure period of 24 hours. Evaluation of skin irritation was made until day 7 according to Draize et al. (J.Pharmacol. Exp. Ther. 82, 377-390 (1944). The test substance proved to be not irritating to the skin.
Reference
The test substance proved to be not irritating to the skin
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient documented and scientifically acceptable
- Principles of method if other than guideline:
- A dose of 50 mg of the test substance was administered into one eye of one male and one female adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with sterile water. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of the ocular reaction was recorded until day 7 according to Draize et al. (J. Pharmacol. Exp. Ther. 82, 377-390 (1944)).
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 1 day
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2 animals
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 h, 24 h, 2 d, 3 d, 6 d, 7 d
- Score:
- 0
- Max. score:
- 13
- Reversibility:
- other: not applicable - score = 0 at any time point
- Other effects:
- at the inspection 1 h after the application of the test substance for 24 hours a slight redness of the treated eye (score = 1) was found. This finding was reversible within 24 h (score = 0).
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
A dose of 50 mg of the test substance was administered into one eye of one male and one female adult New Zealand White rabbit (3-4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with sterile water. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of the ocular reaction was recorded until day 7 according to Draize et al. (J. Pharmacol. Exp. Ther. 82, 377-390 (1944)).
The test substance was not irritating to the eye (score = 0 at any time point).
Reference
The test substance proved to be not irritating to the eye
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
2 white New-Zealand rabbits were treated onto the inside of the ear with ca. 500 mg of the test substances. The test item remained under semiocclusion for 24 hours. Treated animals were inspected for skin effects (erythma, oedema) after removal of plaster and after 1, (2), (3), (4), (5), (6) and 7 days. Total observation time was 7 days. The test substance was not irritating.
In 1 male and 1 female New Zealand white rabbit, 50 mg methyl-2mercaptobenzimidazole, zinc salt or methyl-2-mercaptobenz- imidazole were applied into the conjunctival sac of one eye of each rabbit. The animals were observed for 7 days. The test substances were not irritating.
Justification for selection of skin irritation / corrosion endpoint:
key study used
Justification for selection of eye irritation endpoint:
key study used
Justification for classification or non-classification
skin irritation:
mean value for erythema = 0, mean value for oedema = 0
On the basis of this data a classification is not justified
eye irritation:
mean values for cornea opacity (0); mean values for iris inflammation (0);
mean values for conjunctivae reddening (0), mean values for conjunctivae swelling (0)
On the basis of this data a classification is not justified
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