Registration Dossier
Registration Dossier
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EC number: 211-838-3 | CAS number: 700-13-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment, not to be used for classification and labeling.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Internal BASF method was used
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,3,5-trimethylhydroquinone
- EC Number:
- 211-838-3
- EC Name:
- 2,3,5-trimethylhydroquinone
- Cas Number:
- 700-13-0
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 2,3,5-trimethylbenzene-1,4-diol
- Details on test material:
- - Name of test material (as cited in study report): 2,3,5-trimethylhydroquinone
- Substance No.: 77/749
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: M .GAUKLER, 6050 Offenbach, Germany
- Weight at study initiation: mean 2.8 kg (male), 2.9 kg (female)
- Diet (e.g. ad libitum): Ssniff K, Standarddiät, INTERMAST GMBH, Soest; ad libitum
- Water (e.g. ad libitum): drinking water; ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- Area of exposure: area of 50 cm2 on back and flanks
- Type of wrap if used: inert foil fixed with tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): water, water:Lutrol
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 200 mg/kg bw
- Concentration (if solution): 50% in water
- Constant volume or concentration used: yes - Duration of exposure:
- 24 h
- Doses:
- 200 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: prior to and at the end of study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Mortality:
- no mortality
- Clinical signs:
- other: Transient, reversible signs of irritation were noted for individual animals
- Gross pathology:
- nothing abnormal detected
Applicant's summary and conclusion
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