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Diss Factsheets
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EC number: 203-185-8 | CAS number: 104-21-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- p-methoxybenzyl acetate
- EC Number:
- 203-185-8
- EC Name:
- p-methoxybenzyl acetate
- Cas Number:
- 104-21-2
- Molecular formula:
- C10H12O3
- IUPAC Name:
- 4-methoxybenzyl acetate
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 50 (in two groups at 25)
- Sex: male/female
- Age: 18-58
- Race: B/W - Clinical history:
- healthy
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Dose: 4 and 10 %
- Vehicle: Petrolatum
A pre-test with 5 subjects was performed to determine whether sodium lauryl sulfate pre-treatment was required.
The patch was applied to normal sites on the volar forearms for 48 hours under occlusion and for the main test in five alternate-day 48 h periods.
In the main test the patch site was pre-treated for 24 hours with 5 % aqueous sodium lauryl sulfate under occlusion.
The challenge sites were read on removal of the patch and 24 hours thereafter.
Results and discussion
- Results of examinations:
- The pre-test showed no irritation due to the test substance.
In the main test there were no instances of contact-sensitization from the test substance on the Maximization Test.
Applicant's summary and conclusion
- Conclusions:
- The pre-test showed no irritation due to the test substance.
In the main test there were no instances of contact-sensitization from the test substance (4 and 10 %) on the Maximization Test. - Executive summary:
A test for the skin sensitization properties of the test substance (4 and 10 %) with 2 groups of 25 volunteers was conducted. The pre-test with 5 subjects showed no skin irritation due to the test substance. In the main test the application side was pretreated with 5 % aqueous sodium lauryl sulfate. There were no instances of contact-sensitization from the test substance on the Maximization Test. Therefore it was concluded that it is unlikely that the test substance would present a danger of contact-sensitization in normal, intended use.
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