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Diss Factsheets
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EC number: 203-185-8 | CAS number: 104-21-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000-03-30 to 2000-05-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38409-3: German standard methods for the examination of water, waste water and sludge; general measures of effects and substances (group H); determination of total organic carbon (TOC) (H 3)
- Deviations:
- no
- Principles of method if other than guideline:
- The test substance was stirred in demineralised water. After 24 and 72 h the concentration was analysed through dissolved organic carbon meassurement.
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- 616 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- Remarks on result:
- other: pH value not determined
- Water solubility:
- 627 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- Remarks on result:
- other: pH value not determined
- Water solubility:
- 605 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- Remarks on result:
- other: pH value not determined
- Details on results:
- The concentration measured did not differ for more than 15 % and temperatures were kept constant within ± 2 °C. Thus, all validity criteria were fulfilled.
- Conclusions:
- The water solubility of the test substance was determined to be 616 mg/L at 20 °C.
- Executive summary:
A study was conducted similar to OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 440/2008, Method A.6 to determine the water solubility of the test item. The test was conducted at 20 °C ± 2 °C. The test mixture replicates were stirred at about 600 rpm for 24 and 72 h, respectively. After 24 and 72 h one replicate containing test item and one control replicate were filtered through 0.45 µm and analysed (TOC-analysis). The solubility of the test item was determined as mean of the 24 -72 h time points to be 616 mg/L at 20 ± 2 °C.
Reference
|
24 h |
72 h |
|||
Test item [mg/L] |
Content of carbon [mg/L](1) |
DOC [mg/L] |
Test item [mg/L] |
DOC [mg/L] |
Test item [mg/L] |
1000 |
665 |
417.64 |
627 |
402.56 |
605 |
Solubility of test item [mg/L] (Mean value) |
616 |
DOC-values of test item were corrected by values of control.
(1)= Content of carbon takes into account the purity of test item
Description of key information
The water solubility of the test substance was determined to be 616 mg/L at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 616 mg/L
- at the temperature of:
- 20 °C
Additional information
A study was conducted similar to OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 440/2008, Method A.6 to determine the water solubility of the test item. The test was conducted at 20 °C ± 2 °C. The test mixture replicates were stirred at about 600 rpm for 24 and 72 h, respectively. After 24 and 72 h one replicate containing test item and one control replicate were filtered through 0.45 µm and analysed (TOC-analysis). The solubility of the test item was determined as mean of the 24 -72 h time points to be 616 mg/L at 20 ± 2 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.