Registration Dossier
Registration Dossier
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EC number: 246-770-3 | CAS number: 25265-71-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h LC50 of the structurally related analogue monopropylene glycol (CAS number 57-55-6) to Fathead minnow is 46500 mg/L.
The 96-h LC50 of the structurally related analogue tripropylene glycol (CAS number 24800-44-0) to is > 1000 mg/L.
Furthermore, calculated effect concentrations are available for freshwater fish (96-h LC50 15167 mg/l).
Based on this information it can be assumed that the 96-h LC50 of dipropylene glycol can assumed to be > 1000 mg/L
Key value for chemical safety assessment
Additional information
No reliable data on dipropylene glycol was available. However, Article 13 of the REACH legislation states that, in case no appropriate animal studies are available for assessement, information should be generated whenever possible by means of other than vertebrate animal tests, i.e. applying alternative methods such as in vitro tests, QSARs, grouping and read-across. A study with the structural analogues mono- and tripropylene glycol was available for assessment.
The value that is derived from read-across with the structural analogues is used in the assessment. A full justification for read across within the propylene glycol series is contained in a separate document attached to chapter 13 of the lead registrants IUCLID dossier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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