Registration Dossier
Registration Dossier
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EC number: 201-173-7 | CAS number: 79-06-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documeted study (pre-GLP). Complete study report with analytical data.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- Pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Acrylamide
- EC Number:
- 201-173-7
- EC Name:
- Acrylamide
- Cas Number:
- 79-06-1
- Molecular formula:
- C3H5NO
- IUPAC Name:
- prop-2-enamide
- Details on test material:
- 50.7% aqueous acrylamide solution
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 2 male and 2 female rabbitts
24 hours prior to application the entire trunk of the test animals was clipped
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- Unabraided skin
- Duration of exposure:
- 24 hours
- Doses:
- 200, 795, 1580 and 3160 mg/kg of 50.7% aqueous acrylamide solution
- No. of animals per sex per dose:
- 2 male and 2 female rabbits/group
- Control animals:
- no
- Details on study design:
- The animals were observed for mortality and clinical signs for 14 days.
- Statistics:
- None given
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 141 mg/kg bw
- 95% CL:
- > 710 - < 1 851
- Remarks on result:
- other: 2250 mg test material/kg bw
- Mortality:
- 200 mg test material/kg = 0/4
795 mg test material/kg = 0/4
1580 mg test material/kg = 1/4
3160 mg test material/kg = 3/4 - Clinical signs:
- other: At the two highest exposure levels tremors and incoordination of hindlimbs were noted, and, in addition, the surviving female at 1,612 mg/kg was in poor condition and lost weight. All other animals showed some bodyweight gain at the end of the observation
- Gross pathology:
- No microscopic observations were conducted
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 for acrylamide is 1141 mg acrylamide/kg bw
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