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Diss Factsheets
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EC number: 212-782-2 | CAS number: 868-77-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: retrospective study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Bias-positive: patients of dermatologists or dermal clinics are a cohort preselected for having a problem with the skin, so that no valid assessment of actual prevalence can be done.
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact allergy to (meth)acrylates in the dental series in southern Sweden: simultaneous positive patch test reaction patterns and possible screening allergens
- Author:
- Goon, A.T.J., Isaksson, M., Zimerson, E., Goh, C.L. and Bruze, M.
- Year:
- 2 006
- Bibliographic source:
- Contact Dermatitis 55: 219-226
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- 10- year restrospective study of all patients patch tested to the dental patient series and dental personnel series in the Department of Occupational and Environmental Dermatology, Malmo University Hospital, Sweden- 1 January 1995 through 31 December 2004..
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-hydroxyethyl methacrylate
- EC Number:
- 212-782-2
- EC Name:
- 2-hydroxyethyl methacrylate
- Cas Number:
- 868-77-9
- Molecular formula:
- C6H10O3
- IUPAC Name:
- 2-hydroxyethyl methacrylate
- Details on test material:
- - Name of test material (as cited in study report): 2-hydroxyethyl methacrylate
Constituent 1
Method
- Type of population:
- other: genral and occupational
- Ethical approval:
- not specified
- Subjects:
- 1632 subjects: 1322 dental patients to the dental patient series (977 females and 345 males), 81 dental personnel to the dental patient series (56 females and 25 males), and 229 dental personnel to the dental personnel series (176 females and 53 males).
- Clinical history:
- Dental patients and dental personnel
- Route of administration:
- dermal
- Details on study design:
- The allergens were applied onto small Finn Chambers on Scanpor. The tests were applied to the upper part of the back and left for 48 hours. Tests were read on day 3 (D3) or D4 and D7 by a dermatologist and the reactions were scored according to ICDRG criteria.
Results and discussion
- Results of examinations:
- Of all 1632 patients tested, 48 (37 females and 11 males) had positive results to one or more (methyl)acrylates. Positive patch tests to (meth)acrylate allergens were seen in 2.3% (30/1322) of the dental patients and 5.8% (18/310) of the dental personnel. The most common allergen for both groups was HEMA. Forty-seven out of 48 (98%) had positive patch tests to HEMA.
Applicant's summary and conclusion
- Executive summary:
1632 subjects had been patch tested to either the dental patient series or dental personnel series at the department of Occupational and Environmental Dermatology, Malmo, Sweden. Positive patch tests to (meth)acrylate allergens were seen in 2.3% (30/1322) of the dental patients and 5.8% (18/310) of the dental personnel. The most common allergen for both groups was HEMA. A total of 48 people (30 patients and 18 dental personnel) reacted to methacrylates, and of these, 47 had positive patch tests to HEMA. Of the 47 responding to HEMA, 30 had simultaneous positive reactions to EGDMA. The authors concluded that if only HEMA had been used for screening, all of the sensitive individuals would have been detected. Further, reading sites only on day 3 and not day 7 would have caused 17% of those sensitive to HEMA not to have been identified. This study indicates that between 2-6% of the subjects included in the study at the clinic responded to challenge with HEMA. This prevalence, however, should not be confused with expectations for the general population however because subjects in the study were those already responding to the class of methacrylates.
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