Corn, steep liquor

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

1987

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment.

Data source

Reference

Reference Type:

secondary source

Title:

Unnamed

Year:

1987

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EPA OPP 81-3 (Acute inhalation toxicity)

Deviations:

not specified

GLP compliance:

yes

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lactic acid

EC Number:

200-018-0

EC Name:

Lactic acid

Cas Number:

50-21-5

Molecular formula:

C3H6O3

IUPAC Name:

2-hydroxypropanoic acid

Details on test material:

- Name of test material (as cited in study report): L(+) lactic acid 80%

Test animals

Species:

rat

Strain:

Fischer 344

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

nose only

Vehicle:

other: unchanged (no vehicle)

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Concentrations:

7.94 mg/L (air)

No. of animals per sex per dose:

5 animals/sex

Control animals:

yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 7.94 mg/L air

Any other information on results incl. tables

Animals were observed during exposure for signs of toxicity. Rapid breathing and eye tearing was observed in the treatment group. One and three hours after exposure, the treated and control groups had a hunched posture, red stained fur surrounding the eyes(tearing), ruffled fur, and appeared ungroomed with solid fur. Female rats exposed to the test substance appeared lethargic at one (2/5) and three hours (5/5). The two female rats that were lethargic after 1 hour also had a rapid, shallow breathing and appeared to be gasping after one and three hours. By 24 hours, most animals appeared normal and no unusual behavior or appearance was observed for the remainder of the test period. However, of the treated female rats 4/5 had ruffled, ungroomed fur at 24 hours, and 3/5 had ruffled, ungroomed fur 2, 3 and 4 days after treatment. One female from the treatment group had hunched posture, rapid and shallow breathing, and slight tremors, but these signs were observed on day 5 post-treatment. One female from the treatment group died on day 8 post-treatment. No gross lesions were observed at necropsy.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)