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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: In vitro system with limited significance.

Data source

Reference
Reference Type:
publication
Title:
Estrogenic activities of 517 chemicals by yeast two-hybrid assay
Author:
Nishihara T, Nishikawa J, Kanayama T, Dakeyama F, Saito K, Imagawa M, Takatori S, Kitagawa Y, Hori S, Utsumi H
Year:
2000
Bibliographic source:
J. Health Sci.46, 282-298 (2000)

Materials and methods

Type of study / information:
Type: in vitro estrogenic activity
Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Diphenyl carbonate
EC Number:
203-005-8
EC Name:
Diphenyl carbonate
Cas Number:
102-09-0
Molecular formula:
C13H10O3
IUPAC Name:
diphenyl carbonate
Details on test material:
Most chemicals were of the highest grade commercially available (purity for diphenyl carbonate not given).

Results and discussion

Any other information on results incl. tables

Diphenyl carbonate showed a REC10 of >3x10 EE-4 M and is therefore regarded as negative in this assay.

Applicant's summary and conclusion