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EC number: 203-005-8 | CAS number: 102-09-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 15.1 °dH (M4-Medium)
- Test temperature:
- 21 °C
- pH:
- 8.1
- Dissolved oxygen:
- oxygen concentration between 4.0 and 7.1 mg/L
- Details on test conditions:
- conditions of aquaculture: SOP 2030-7700204-98-D
water for aquaculture: M4-medium according to Elendt, version of BGA (1992) - Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 6.3 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 18.2 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- other: EC75
- Effect conc.:
- 18.2 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 6.3 - < 18.2 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: graphic interpolation
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 2.1 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Estimation based on half-life (39.9 hours)
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 8.5 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Estimation based on half-life (39.9 hours)
- Duration:
- 48 h
- Dose descriptor:
- other: EC75
- Effect conc.:
- 8.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Estimation based on half-life (39.9 hours)
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6.5 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Estimation based on half-life (39.9 hours), graphic interpolation (linear)
- Conclusions:
- Under the conditions of the study the 48 hour EC50 was determined to be 6.5 mg/L.
- Executive summary:
The study was conducted according to the standardised guideline EU Method C.2 under GLP conditions.
During the study Daphnia magna were exposed to the test material at nominal concentrations of 5, 10 and 20 mg/L under static conditions for 48 hours. Ten daphnids were used per concentration in 20 mL test medium, with two replicates. The stock solution was prepared by dissolving in water an amount of test material approximately 5 times higher (60 mg/L) than the corresponding water solubility; this mixture was then stirred for 24 hours and the suspension was filtered in order to remove the undissolved particles. Analytical monitoring was performed by measuring the total organic carbon (TOC).
Due to the hydrolysis of diphenyl carbonate in the presence of water, forming phenol and carbon dioxide, the effective concentrations of diphenyl carbonate are estimated for each test concentration.
At the effective concentration of 6.3 mg/L (nominal concentration of 5 mg/L) no adverse effect was observed. At the effective concentration of 18.2 mg/L (nominal concentration of 20 mg/L), an immobilisation of 75 % of the daphnids was observed. With the assumption that the half-life of diphenyl carbonate is about 40 hours under abiotic conditions in a buffered medium, and assuming a water solubility of 13 mg/L, the geometric mean over time is 8.5, 4.1 and 2.1 mg/L at the nominal test concentrations of 20, 10 and 5 mg/L, respectively. By graphic interpolation (linear) the resulting effective 48 h EC50 is 6.5 mg/L.
Reference
At the effective concentration of 6.3 mg/l (nominal concentration of 5 mg/l), related to the TOC single results at 0 and 48 h, no adverse effect was observed.
At the effective concentration of 18.2 mg/l (nominal
concentration of 20 mg/l), related to the TOC single results at 0 and 48 h, an immobilisation of 75 % of the daphnids was observed.
Due to the hydrolysis of diphenyl carbonate in the presence of water, forming phenol and carbon dioxide, the effective
concentrations of diphenyl carbonate are estimated for each test concentration. With the assumption that the half-life of
diphenyl carbonate is about 40 hours under abiotic conditions in a buffered medium, and assuming a water solubility of 13 mg/l, the
geometric mean over time is 8.5 mg/l, 4.1 mg/l and 2.1 mg/l at the nominal test concentrations of 20 mg/l, 10 mg/l and
5 mg/l. By graphic interpolation (linear) the resulting effective 48 h EC50 is 6.5 mg/l.
Description of key information
The toxicity of diphenyl carbonate to aquatic invertebrates (Daphnia magna) was assessed according to EU Method C.2 (Bayer, 1999a). The effective concentration 48h EC50 was determined to 6.5 mg/L by graphic interpolation (linear).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 6.5 mg/L
Additional information
As agreed in the OECD ICCA/HPV-program, a half-life of 39.9 hours and a water solubility of 13 mg/L were used for the interpretation of aquatic data. The nominal diphenyl carbonate concentrations were converted to effective concentrations by approximation as geometric means over time. It is considered that the observed effects cover both the toxicity of diphenyl carbonate and the toxicity of the degradation products.
Short term toxicity to Daphnia magna
This endpoint is addressed with 1 key study (Bayer, 1999a).The study was conducted according to the standardised guideline EU Method C.2 under GLP conditions and was awarded a reliability score of 2 in accordance with the criteria for assessing data quality as set forth by Klimisch et al. (1997).
Daphnia magna were exposed to the test material at nominal concentrations of 5, 10 and 20 mg/L under static conditions for 48 hours. Ten daphnids were used per concentration in 20 mL test medium, with two replicates. The stock solution was prepared by dissolving in water an amount of test material approximately 5 times higher (60 mg/L) than the corresponding water solubility; this mixture was then stirred for 24 hours and the suspension was filtered in order to remove the undissolved particles. Analytical monitoring was performed by measuring the total organic carbon (TOC).
Due to the hydrolysis of diphenyl carbonate in the presence of water, forming phenol and carbon dioxide, the effective concentrations of diphenyl carbonate are estimated for each test concentration.
At the effective concentration of 6.3 mg/L (nominal concentration of 5 mg/L) no adverse effect was observed. At the effective concentration of 18.2 mg/L (nominal concentration of 20 mg/L), an immobilisation of 75 % of the daphnids was observed. With the assumption that the half-life of diphenyl carbonate is about 40 hours under abiotic conditions in a buffered medium, and assuming a water solubility of 13 mg/L, the geometric mean over time is 8.5, 4.1 and 2.1 mg/L at the nominal test concentrations of 20, 10 and 5 mg/L, respectively. By graphic interpolation (linear) the resulting effective 48 h EC50 is 6.5 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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