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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data available
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The method used is similar to the acute standard method but the method and the results are poorly described.

Data source

Reference
Reference Type:
publication
Title:
Range finding toxicity data, list III
Author:
Smyth HF, Carpenter CP, Weil CS
Year:
1949
Bibliographic source:
J Ind Hyg Tox 31: 60-61

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No guideline available at the date of the study. Method used is the standard acute method. More details on the method are given in previous publications. These details have been added hereafter.
The publications are:
Smyth & Carpenter (1944): The place of the range-finding test in the industrial toxicology laboratory. J Ind Hyg Tox 26: 269-273
Smyth & Carpenter (1948): Further experience with the range finding test in the industrial toxicology laboratory. J Ind Hyg Tox 30: 63-68

GLP compliance:
no
Remarks:
Study made before the GLP creation
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl sulphate
EC Number:
200-589-6
EC Name:
Diethyl sulphate
Cas Number:
64-67-5
Molecular formula:
C4H10O4S
IUPAC Name:
diethyl sulfate
Details on test material:
No data available

Test animals

Species:
rat
Strain:
Sherman
Sex:
not specified
Details on test animals or test system and environmental conditions:
No further information
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 90-120 g
- Fasting period before study: none
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data


ENVIRONMENTAL CONDITIONS
no data


IN-LIFE DATES: no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
No data
Doses:
4 doses in geometrical series, no further information
No. of animals per sex per dose:
5 animals per doses but no data on sex
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Statistics:
LD50 determined using the Thompson method

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
880 mg/kg bw
95% CL:
760 - 1 010
Mortality:
No data
Clinical signs:
other: No data
Gross pathology:
No data
Other findings:
No data

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
According to these results, DES is considered as harmful by ingestion
Executive summary:

Oral LD50 of DES has been determined in rats using 4 doses administrated to groups of 5 non fasted animals.

The LD 50 is 880 mg/kg (760 -1010).