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EC number: 202-951-9 | CAS number: 101-54-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study and guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of 4-aminodiphenylamine
- Author:
- Randall, D. J. and Bannister R.M.
- Year:
- 1 990
- Bibliographic source:
- Acute Toxicity Data 1: 63 - 64
- Reference Type:
- secondary source
- Title:
- Summary with cover letter dated 10/18/88; NTIS/OTS 516609, Doc I.D. 89-890000009 (1988)
- Author:
- EPA-OTS
- Year:
- 1 988
- Bibliographic source:
- Monsanto Co. (1984) Acute toxicity/irritation studies with 4-aminodiphenylamine (4-ADPA). Study BD-84-077 Summary with cover letter dated 10/18/88; NTIS/OTS 516609, Doc I.D. 89-890000009 (1988)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA November 1982, section 81-4, pimary eye irritation study; TSCA EPA August 1982, acute exposure, pimary eye irritation
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-(4-aminophenyl)aniline
- EC Number:
- 202-951-9
- EC Name:
- N-(4-aminophenyl)aniline
- Cas Number:
- 101-54-2
- Molecular formula:
- C12H12N2
- IUPAC Name:
- N1-phenylbenzene-1,4-diamine
- Details on test material:
- 4-ADPA, purity 98.9 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Amount applied: 0.1 ml
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- up tp 14 d
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 h (mean)
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- other: reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 h (mean)
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- other: reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 h (mean)
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- other: reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #4
- Time point:
- other: 24, 48, 72 h (mean)
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 14 d
- Remarks on result:
- other: reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #5
- Time point:
- other: 24, 48, 72 h (mean)
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 d
- Remarks on result:
- other: reversible
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #6
- Time point:
- other: 24, 48, 72 h
- Score:
- 1.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 d
- Remarks on result:
- other: reversible
- Other effects:
- 4-ADPA produced moderate but reversible ocular irritation in all animals. All six animals exhibited moderate to severe conjunctival irritation (redness, chemosis, discharge and/or necrosis), three exhibited corneal opacity and/or ulceration and one had iridial damage (at one hour only). Two animals were noted to have desquamation on the eyelids. All six animals were free of significant ocular irritation within 7 to 14 days after instillation of the test material.
Any other information on results incl. tables
RS-Freetext:
INDIVIDUAL SCORES (1, 24, 48, 72 h/animal)
- Cornea:
0, 0-1, 0-1, 0-1
0, 1, 0-1, 0-1
0-1, 2, 1, 0-1
0, 0-1, 0, 0-1
0-1, 0-1, 0, 0
0-1, 0-1, 0-1, 0
- Iris:
0-1, 0-1, 0, 0
0-1, 0,1, 0-1, 0
0-1, 0-1, 0-1, 0
1, 0, 0, 0
0-1, 0, 0, 0
0-1, 0, 0, 0
- Conjunctival redness:
1, 2, 2, 2
1, 3, 2, 2
1, 3, 2, 2
2, 2, 2, 2
1, 2, 1, 1
1, 2, 2, 1
- Conjunctival chemosis:
3, 2, 1, 1
3, 2, 1, 1
3, 2, 1, 1
3, 2, 2, 2
2, 1, 1, 1
2, 2, 1, 1
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information
- Executive summary:
In a guideline study moderate ocular irritation from one hour to three days was noted in each of 6 rabbits after instillation of 0.1 ml of finely ground 4-ADPA into the conjunctival sac. Three animals exhibited corneal opacities or ulceration. All six animals were free of ocular effects within 7 to 14 days (Monsanto 1984).
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