Isodecyl methacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: OSHA toxicity screening test. Limited documentation of the study.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Guideline:

other: OSHA Toxicity Screening Test

GLP compliance:

no

Test type:

other: single dose

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Isodecyl methacrylate

EC Number:

249-978-2

EC Name:

Isodecyl methacrylate

Cas Number:

29964-84-9

Molecular formula:

C14H26O2

IUPAC Name:

2-methylnonyl 2-methylprop-2-enoate

Details on test material:

2-Propenoic acid, 2-methyl-, isodecyl ester purity not specified, but commercial grade assumed.

Test animals

Species:

rat

Strain:

other: Albino

Sex:

male

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

unchanged (no vehicle)

Doses:

Dosage: 5000 mg/kg

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations:
after 1h; 2h; 3h; 4h; 1d; 2d; 3d; 4d; 5d; 6d; 7d; 14d
- Necropsy of survivors performed: yes

- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

Do mortality observed in the concentration of 5000 mg/kg dw (0/6).

Clinical signs:

other: After one hour: ruffled fur and hypoactivity After one day: diarrhea All animals had recovered on day 2

Gross pathology:

No gross pathologic alterations were noted.

Other findings:

not reported

Any other information on results incl. tables

Animal no.	Body weight on day 0	Body weight on day 14
1	171	327
2	171	319
3	173	329
4	162	300
5	164	304
6	174	332

 

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In an OSHA toxicity screening test in male Albino rats on acute oral toxicity with Isodecyl methacrylate, the test substance was administered undiluted with a dosage of 5000 mg/kg. b.w. Some mild signs of intoxication as ruffled fur, hypoactivity and diarrhea were reversible within 2 days.
The determined LD50 was > 5000 mg/kg.

Executive summary:

In an OSHA toxicity screening test in male Albino rats on acute oral toxicity with Isodecyl methacrylate, the test substance was administered undiluted with a dosage of 5000 mg/kg. b.w. Some mild signs of intoxication as ruffled fur, hypoactivity and diarrhea were reversible within 2 days.

The determined LD50 was > 5000 mg/kg.

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