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EC number: 204-337-6 | CAS number: 119-61-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Benzophenone was tested in several standard in vitro and in vivo studies performed according to recent guidelines. All of these studies gave no indications for a mutagenic/genotoxic potential.
In vitro:
Bacterial Reverse Mutation Assay equivalent or similar to OECD Guideline 471: negative in S. typhimurium TA1535, TA1537, TA98 and TA100 both with and without metabolic activation (Mortelmans et al., 1986; NTP, 2006)
Bacterial Reverse Mutation Assay equivalent or similar to OECD Guideline 471: negative in S. typhimurium TA98, TA100, TA1535, TA1537 and TA1538 both with and without metabolic activation (Seifried et al., 2006)
DNA damage and repair assay (unscheduled DNA synthesis in mammalian cells in vitro): negative in E. coli W3110 (Pol A+) and p3478 (Pol A-) both with and without metabolic activation (Fluck et al., 1976)
Mouse lymphoma assay equivalent or similar to OECD Guideline 476 (In vitro Mammalian Cell Gene Mutation Test): negative in L5178Y cells both with and without metabolic activation (Seifried et al., 2006)
In vivo:
Micronucleus assay according to OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test): negative (NTP, 2000)
Micronucleus assay equivalent or similar to OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test): negative (Abramsson-Zetterberg & Svensson, 2011)
Short description of key information:
In vitro studies:
Bacterial Reverse Mutation Assay equivalent or similar to OECD Guideline 471: negative in S. typhimurium TA1535, TA1537, TA98 and TA100 both with and without metabolic activation (Mortelmans et al., 1986; NTP, 2006)
Bacterial Reverse Mutation Assay equivalent or similar to OECD Guideline 471: negative in S. typhimurium TA98, TA100, TA1535, TA1537 and TA1538 both with and without metabolic activation (Seifried et al., 2006)
DNA damage and repair assay (unscheduled DNA synthesis in mammalian cells in vitro): negative in E. coli W3110 (Pol A+) and p3478 (Pol A-) both with and without metabolic activation (Fluck et al., 1976)
Mouse lymphoma assay equivalent or similar to OECD Guideline 476 (In vitro Mammalian Cell Gene Mutation Test): negative in L5178Y cells both with and without metabolic activation (Seifried et al., 2006)
In vivo studies:
Micronucleus assay according to OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test): negative (NTP, 2000)
Micronucleus assay equivalent or similar to OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test): negative (Abramsson-Zetterberg & Svensson, 2011)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The experimental data are not indicating a possible mutagenic/genotoxic potential. Therefore, there is no need for a classification according to the criteria of EC Directive 1272/2008 and of the GHS.
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