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EC number: 231-831-9 | CAS number: 7758-05-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental data of various test chemicals
- Justification for type of information:
- Experimental data of various test chemicals is from collection of data
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- WoE report is based on three short term toxicity study of test chemical on the mobility of aquatic invertebrates.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- 1: The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 2 mg of the test substance in 20 ml of ADaM’s media. Achieving test concentrations of 100 mg/L, respectively.
- Test organisms (species):
- other: 1: daphnia magna, 2: Dreissena polymorpha
- Details on test organisms:
- 2: - Common name: Water flea
- Source: Own breeding of daphnia magna
- Food: No feeding after hatching
3: LIFE STAGE : Adult(s)COMMENT : 1.5-2.0 cm - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- 24 hrs in 3rd study
- Post exposure observation period:
- 24 and 48 hrs
- Hardness:
- 1: 153.5 mg of CaCO3
- Test temperature:
- 1: 20±2
- pH:
- 1: 7.1
2: 7 - Nominal and measured concentrations:
- 1: 100 mg/l
- Details on test conditions:
- 1: TEST SYSTEM
- Test vessel: Glass beaker
- Aeration: No aeration during experiment
- Material, size, headspace, fill volume: 25 ml of glass beaker filled with 20 ml media having headspace of 5 ml
- No. of organisms per vessel: 10 daphnids
Test water:
ADaM’s media is used, prepared in MiliQ water.
OTHER TEST CONDITIONS
- Photoperiod:16 hours light and 8 hours dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : pH, Dissolved oxygen, temperature and mobility
- Results used to determine the conditions for the definitive study: Mobility
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 1st study
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 226 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 2nd study
- Validity criteria fulfilled:
- no
- Conclusions:
- 1: Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test chemical on freshwater daphnia magna was determine to be 100 mg/L.
2: The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. - Executive summary:
Various studies for the test chemical and structurally and functionally similar read across chemical were reviewed and summarized for the determination of chemical effect on the mobility of test organisms aquatic invertebrates which are as follows:
The study was designed to assess the toxic effects of the test compound on the test Daphnids. Beaker containing 20ml of media with 10 Daphinds. A semi-static procedure was used for the study and it was conducted in compliance with the OECD guideline 202. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 2 mg of the test substance in 20 ml of ADaM’s media. Achieving test concentrations of 100 mg/L, respectively. The test concentrations selected for the study was 100 mg/L. The test vessels used were all glass beaker having the water capacity of 25ml, in each vessel 10 daphnia were incorporated. Observations (immobility, pH, Temperature, dissolved oxygen content) were recorded after 24 and 48hours of the start of the experiment. Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test chemical on freshwater daphnia magna was determine to be 100 mg/L. This value indicates that the substance is likely to be non hazardous to aquatic invertebrate and cannot be classified as per the CLP criteria.
Similar study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.
Thus based on the above effects, chemical consider to be nontoxic and not classified as per the CLP classification criteria.
Reference
Description of key information
1: Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test material on test daphnia was determine to be > 100 mg/L.
2: The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Various studies for the test chemical and structurally and functionally similar read across chemical were reviewed and summarized for the determination of chemical effect on the mobility of test organisms aquatic invertebrates which are as follows:
The study was designed to assess the toxic effects of the test compound on the test Daphnids. Beaker containing 20ml of media with 10 Daphinds. A semi-static procedure was used for the study and it was conducted in compliance with the OECD guideline 202. The test substance was soluble in water. Therefore, the test solution was prepared by dissolving 2 mg of the test substance in 20 ml of ADaM’s media. Achieving test concentrations of 100 mg/L, respectively. The test concentrations selected for the study was 100 mg/L. The test vessels used were all glass beaker having the water capacity of 25ml, in each vessel 10 daphnia were incorporated. Observations (immobility, pH, Temperature, dissolved oxygen content) were recorded after 24 and 48hours of the start of the experiment. Based on nominal concentrations, experimental median effective Concentrations [EC-50 (48 h)] for test chemical on freshwater daphnia magna was determine to be 100 mg/L. This value indicates that the substance is likely to be non hazardous to aquatic invertebrate and cannot be classified as per the CLP criteria.
Similar study was conducted to determine the effect of test chemical on Dreissena polymorpha. Test conducted under the static system on 1.5-2.0 cm old freshwater Dreissena polymorpha. 24 hrs of exposure period were provided. The lethal concentration (LC50) value of test chemical on aquatic invertebrates (Dreissena polymorpha) in a 24 hrs study by observing effect on mortality was determine to be 226 mg/L. Based on the LC50 value, chemical consider to be nontoxic and can be consider to be not classified as per the CLP classification criteria.
Thus based on the above effects, chemical consider to be nontoxic and not classified as per the CLP classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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