Registration Dossier
Registration Dossier
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EC number: 248-003-8 | CAS number: 26787-78-0
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence. Three studies available. In a ready biodegradability test (OECD 301D, no GLP), the test item was found to be not readily biodegradable. In two inherent biodegradability tests (OECD 302B, no GLP; and OECD 302D, no GLP), the test item was found to be inherently biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
Additional information
Weight of evidence. Five studies available:
- In a ready biodegradability test (Längin, 2009. OECD 301D, no GLP), the test item was found to be not readily biodegradable. Altough amoxicillin was not ready biodegradable in the Closed Bottle test, primary abiotic elimination was 100% within 14 days.
- In another ready biodegradability test (Alexy, 2004. OECD 301D, no GLP), the test item was found to be not readily biodegradable, with a degradation of 3% (14d) and 5% (28d). However, elimination was 92%, due to hydrolisis of the β-lactam ring.
In two inherent biodegradability tests, the test item was found to be inherently biodegradable.
- In one of the tests for inherent biodegradability (Längin, 2009. OECD 302B, no GLP), primary elimination of amoxicillin was completed within 4 days. The test item underwent fast abiotic opening of the four membered ß-lactam ring by hydrolysis. The resulting transformation product is further biodegraded to compound B by a loss of the phenol moiety. Compound B is only mineralized further through biotic means.
- In another test (Andreozzi, 2004. OECD 302D draft, no GLP), the initial test item concentration declined approximately 10 times after 5h, indicating a fast biodegradation process. The adsorption process was taken into account in the biodegradation kinetic calculation. The constant for biodegradation/adsorption was determined to be 0.443 h-1. The biodegradation process was identified as the faster one.
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