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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Pre-GLP, pre-guideline study, which is to a great extent according to principles similar to those described in OECD TG 401

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1964

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl hexanoate
EC Number:
204-642-4
EC Name:
Allyl hexanoate
Cas Number:
123-68-2
Molecular formula:
C9H16O2
IUPAC Name:
allyl hexanoate
Details on test material:
Name: Allyl caproate (allyl hexanoate)
No further details provided

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Young, adult rats
- 180 to 350 g
- Animals were fasted 18 hours prior to oral exposure

ENVIRONMENTAL CONDITIONS
- No details on environmental conditions provided

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
No details reported
Doses:
Not reported
No. of animals per sex per dose:
Five males, five females per dose group
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: not reported
Statistics:
LD50 values were computed by the method of Litchfield and Wilcoxon (1949)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
218 mg/kg bw
Based on:
test mat.
95% CL:
186 - 255
Mortality:
Animals were found dead between 4 and 18 hours after single oral exposure
Clinical signs:
other: Depression, scrawny appearance
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance was acutely toxic to rats after a single oral exposure. Due to the observed LD50 of 218 mg/kg bw the substance is to be classified into Acute Toxicity Hazard Category 3 according to the CLP regulation (second amendment of March 2011).
Executive summary:

The acute oral toxicity of the test substance allyl caproate (allyl hexanoate) was studied in a pre-GLP, pre-guideline study which to a great extent followed the standard acute method described in OECD TG 401. Groups of 10 rats of the Osborne-Mendel strain evenly distributed between the sexes received single oral doses of the test substance by oral gavage. The animals were then observed for signs of toxicity during a period of 14 days. Non-mortal clinical effects including depression and scrawny appearance were observed. In this study, mortality of exposed animals was observed between 4 and 18 hours after a single oral exposure. The LD50 value calculated by the method of Litchfield and Wilcoxon (1949) was 218 mg/kg bw with a 95% confidence level ranging from 186 to 255 mg/kg bw. This LD50 value triggers classification according to CLP (second amendment of March 2011) into Acute Toxicity Hazard Category 3.