p-phenylbenzaldehyde

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

No GLP and guideline mentioned. Basic data are given in the study report summary.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1987

Report date:

1987

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

not specified

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

p-phenylbenzaldehyde

EC Number:

221-742-3

EC Name:

p-phenylbenzaldehyde

Cas Number:

3218-36-8

Molecular formula:

C13H10O

IUPAC Name:

[1,1'-biphenyl]-4-carbaldehyde

Test material form:

not specified

Test animals

Species:

rat

Strain:

Wistar

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

olive oil

Doses:

500,1000, 2000, 4000 mg/kg

No. of animals per sex per dose:

10/group

Control animals:

yes

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LD50

Effect level:

1 130 - 2 040 mg/kg bw

Remarks on result:

other: p=0.05

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

1 000 - 2 000 mg/kg bw

Mortality:

Dose level Mortality (final)
(mg/kg) male female
500 0/10 0/10
1000 0/10 3/10
2000 9/10 6/10
4000 10/10 10/10
Olive oil 0/10 0/10

At the administration at 2000 mg/kg or 4000mg/kg, a large number of animals died by Day 4.

Clinical signs:

other: The symptoms of intoxication included sedation, prone, ataxia and collapse were observed. And

Gross pathology:

In dead animals, congestion and oedema of lung, necrosis and ulceration of forestomach were observed.
An in survival animals, thickening of the forestomach mucosa was observed.

Applicant's summary and conclusion

Interpretation of results:

Category 4 based on GHS criteria

Conclusions:

The acute oral LD50 value (rat) was determined to be 1000-2000mg/kg for males and 1510 (1130-2040, p=0.05) mg/kg for females.

Executive summary:

The acute oral toxicity test of the test substance revealed an acute oral LD₅₀ (rat) value of 1000 - 2000mg/kg for males and 1510 (1130 - 2040, p = 0.05) mg/kg for females. The symptoms of intoxication included sedation, prone, ataxia and collapse. After the administration of 2000 mg/kg or 4000 mg/kg, a large number of animals died by day 4. In dead animals, congestion and oedema of lung, necrosis and ulceration of forestomach were observed. In survival animals, thickening of the forestomach mucosa was observed.