Registration Dossier
Registration Dossier
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EC number: 229-552-2 | CAS number: 6606-65-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
From available in vitro and in vivo genotoxicity assays, it can be summarized that n-butyl cyanoacrylate is not genotoxic. A commercial formulation containing 97% of n-butyl cyanoacrylate was considered to be non-mutagenic in strains of Salmonella typhimurium and extracts from the polymerized material were considered non-clastogenic in cultured human lymphocytes and in mouse bone marrow.
Short description of key information:
- REACH_negative | S. typhimurium TA 1535, TA 1537, TA 98 and TA 100 | OECD 471 | with and without | #key study#
- REACH_negative | human lymphocytes | OECD 473 | with and without | #key study#
- REACH_negative | S. typhimurium TA 100, TA 1535, TA 1537 | Ames Test | - |
- REACH_negative | mouse (male/female) | OECD 474 | Polymerised Indermil#key study#
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the overall weight of evidence, it was concluded that n-butyl cyanoacrylate is not considered to be genotoxic and thus needs no classification and labelling.
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