Registration Dossier
Registration Dossier
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EC number: 229-552-2 | CAS number: 6606-65-1
Endpoint summary
Administrative data
Description of key information
EYE IRRITATION:
- REACH_Lit_effective ophtalmological method | human | Clinical Experience with n-butyl cyanaoacrylate (Leahey et al) |
- REACH_Lit_effective alternative to sutures | human | Efficacy of bioadhesives in scleral tunnel phacoemulsification in eyes (Alio et al) |
- REACH_Lit_safe healing technique | human | Clinical experience with cyanoacrylate tissue adhesive (Moschos et al) |
- REACH_Lit_effective dental treatment | human | Treating Dentin Hypersensitivity (Perez et al) |
- REACH_Lit_highly effective | human | Effectiveness of Isobutyl Cyanoacrylate for Treatment of Corneal Perforations (Setlik) | #Analogy#
Additional information
Exposure related observations in humans - Literature with regard to eye irritation
Much experience from clinical observations and investigations in humans is available.
Various authors describe that the use of n-butyl cyanoacrylate (as well as the structural analogue isobutyl cyanoacrylate) offers a safe technique for healing corneal wounds and is an effective alternative to classical sutures (e.g. in scleral tunnel cataract surgery or for treatment of corneal perforations). The case reports and clinical studies describe a direct application of the adhesive onto the eye (cornea) which gives an indication on the compatibility of the tissue adhesive on eyes. It is summarized that n-butyl cyanoacrylate can well be used as wound barrier in ocular surgery with a low side effect profile. Irritation was not mentioned in any of the publications as contraindication for the use of n-butyl cyanoacrylate in eye surgery.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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