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Diss Factsheets
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EC number: 236-537-4 | CAS number: 13423-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12/17/85-12/19/85
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to a guideline study witha acceptable restrictions (e.g. non GLP)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Principles of method if other than guideline:
- Study conducted according to The United States Deprtment of Transportation Regulations
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrahydro-3-methylfuran
- EC Number:
- 236-537-4
- EC Name:
- Tetrahydro-3-methylfuran
- Cas Number:
- 13423-15-9
- Molecular formula:
- C5H10O
- IUPAC Name:
- tetrahydro-3-methylfuran
- Details on test material:
- Purity greater than 98%
Tetrahydrofuran listed as contaminant.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Animals were obtained from Buckshire Company and supplied food and water ad libitum. Rabbits were quarantined, weighed and observed for
general health for two weeks. Environmental conditions of the rooms were targeted for a temperature of 20 °C +/- 2 °C and relative humidity of 50 % +/- 10%. Excursions outside these ranges were of small magnitude and/or brief duration and did not adversely affect the validity of the study.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24 and 48 hours after application
- Number of animals:
- 6
- Details on study design:
- On the day prior to study initiation, the hair of 1 male and 5 female New Zealand White rabbits were closely clipped to expose the back from the scapular to the lumbar region. The rabbits weighed from 3146 to 4126 grams on the day of treatment. A 0.5 ml aliquot of 3-methyl-tetrahydrofuran was applied to test site beneath a 1-inch gauze square that was held in place with tape. The test site was then occluded with rubber sheeting for 4 hours, wiped with paper towels and scored according to the Draize scale. The adjacent areas of the untreated skin were used for comparison.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 1
- Time point:
- other: 4 to 48 hours
- Score:
- 1
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- other: 4 to 48 hours
- Score:
- 1.5
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- other: 4 to 48 hours
- Score:
- 2.5
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 4
- Time point:
- other: 4 to 48 hours
- Score:
- 4
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 5
- Time point:
- other: 4 to 48 hours
- Score:
- 4
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 6
- Time point:
- other: 4 to 48 hours
- Score:
- 4
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 1
- Time point:
- other: 4 to 48 hours
- Score:
- 0.67
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- other: 4 to 48 hours
- Score:
- 2.33
- Max. score:
- 3
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- other: 4 to 48 hours
- Score:
- 2.67
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 4
- Time point:
- other: 4 to 48 hours
- Score:
- 3
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 5
- Time point:
- other: 4 to 48 hours
- Score:
- 3.33
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 6
- Time point:
- other: 4 to 48 hours
- Score:
- 3
- Max. score:
- 4
Any other information on results incl. tables
Erythema |
Edema |
|||||
Response |
4 hr |
24 hr |
48 hr |
4 hr |
24 hr |
48 hr |
Severe |
1 / 6; 2 / 6 (N); 1 / 6 (SN) |
1 / 6 (N); 1 / 6 (SN,B); 1 / 6 (N, B) |
1 / 6 (N); 1 / 6 (N, B) |
4 / 6 |
0 / 6 |
0 / 6 |
Moderate |
0 / 6 |
1 / 6 |
0 / 6 |
1 / 6 |
5 / 6 |
1 / 6 |
Mild |
0 / 6 |
0 / 6 |
2 / 6, 1 / 6 (B) |
0 / 6 |
0 / 6 |
2 / 6 |
Slight |
2 / 6 |
2 / 6 |
1 / 6 |
1 / 6 |
1 / 6 |
2 / 6 |
No Response |
0 / 6 |
0 / 6 |
0 / 6 |
0 / 6 |
0 / 6 |
1 / 6 |
N=Necrosis; SN=Superficial necrosis; B = Blanching; |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study 3 -methyl-tetrahydrofuran was a corrosive agent when applied to the clipped intact skin of rabbits.
- Executive summary:
When 3-methyl-tetrahydrofuran (3-meTHhF; 0.5 ml) was placed onto the skin of clipped rabbits and left covered for 4 hrs and then wiped and covered with gauze, it produced slight erythema in 2 of 6 rabbits and severe erythema in 4 of the 6 rabbits; 2 rabbits also had necrosis and 1 had superficial necrosis within 4 hours post treatment. Slight to severe edema was observed in all rabbits at 4 hours. Approximately 24 hours post treatment, a total of 3 rabbits had severe erythema with necrosis or superficial necrosis. Slight or moderate edema was observed in all rabbits at 24 hours. At 48 hours, 4 rabbits had slight or mild erythema and 2 rabbits had severe erythema with necrosis; slight to moderate edema was observed in 5 rabbits. Blanching was observed in 2 rabbits at 24 and 48 hours post treatment. Under the conditions of this study 3 -meTHF was a corrosive agent when applied to the clipped intact skin of rabbits.
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