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Diss Factsheets
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EC number: 236-537-4 | CAS number: 13423-15-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 1.1 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 11 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.11 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 0.23 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 5.86 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.59 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.53 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Sufficient data are available for the derivation of PNEC values for tetrahydro-3-methylfuran (3-methyl-THF), including a 96-hr LC50 value in freshwater fish (Pimephales promelas) of 1100 mg/L from a non-GLP OECD 203 guideline study (DuPont, 1986) which served as the starting point. Other data considered for PNEC derivation included a 48-hr LC50 value in invertebrates (Daphnia magna) of 1742 mg/L from a non-GLP OECD 202 guideline study (DuPont 1980), an 8-day Toxicity Threshold Concentration (TTC) value (equivalent to EC3) in aquatic algae (Scenedesmus quadricauda) of 1850 mg/L from a non-GLP EC.3.-equivalent guideline study (Bringmann, 1976), and a 33-day NOEC value of 108 mg/L from a non-GLP / non-guideline study (Call, 1985), all of which were data obtained on the read-across substance (tetrahydrofuran) and to which a 2-fold safety factor was applied. Even with the 2-fold safety factor, the measured acute value on 3-methyl-THF, with an assessment factor of 1000, yielded the lowest and most reliable PNEC. An equivalent value would result by using the 33 -day NOEC of 108 mg/L from the long-term study on the read-across substance, which includes the 2-fold safety factor, and then applying an assessment factor of 100. From this single aquatic PNEC value, all other PNECs were derived according to the R.10 REACH Guidance either by applying the specified assessment factor or, in the case of sediments and soil, by applying the equilibrium partitioning coefficient method.
Conclusion on classification
Tetrahydro-3-methylfuran (3-methyl-THF) does not meet the criteria for classification as hazardous to the environment on the basis of a 96-hr LC50 value in freshwater fish (Pimephales promelas) of 1100 mg/L from a non-GLP OECD 203 guideline study (DuPont, 1986) and a PBT Assessment that concludes the substance is not PBT or vPvB.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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