Registration Dossier
Registration Dossier
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EC number: 260-375-3 | CAS number: 56773-42-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: observation time 7 days, short documentation, low dose 50 mg
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- 1 male and 1 female New Zealand white rabbit, 50 mg/rabbit was applied into the conjunctival sac of one eye of each rabbit, observation time: 7 days, evaluation according Draize
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetraethylammonium heptadecafluorooctanesulphonate
- EC Number:
- 260-375-3
- EC Name:
- Tetraethylammonium heptadecafluorooctanesulphonate
- Cas Number:
- 56773-42-3
- Molecular formula:
- C8H20N.C8F17O3S
- IUPAC Name:
- N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonate
- Details on test material:
- no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 7 days
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 120 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable (score = 0 at any time point)
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 120 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: not applicable (score = 0 at any time point)
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 5 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 120 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable (score = 0 at any time point)
- Other effects:
- no data
Any other information on results incl. tables
A slight reddening for a short term was caused by the test substance due to a mechanical irritation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
2 white New zealand rabbits received a dose of 50 mg/animals of the test substance in the conjunctival sac of one eye each. Postexposure period was 7 days.
The test substance was not irritating (a slight reddening for a short term was caused by the test substance due to mechanical irritation)
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