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Diss Factsheets
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EC number: 210-415-0 | CAS number: 615-20-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1958
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of certain benzimidazoles and reated compunds upon azo dye destraction by liver homogenates
- Author:
- Clayton S.C.
- Year:
- 1 958
- Bibliographic source:
- Proc. Soc. Exp. Biol. Med. 97, 510-512
Materials and methods
- Principles of method if other than guideline:
- Assay on the effect of 2-Chlorobenzothiazole on the activities of azo dye degrading enzymes in rat liver homogenates
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- other: Effect on enzymes enabling azo dye degradation
Test material
- Reference substance name:
- 2-chlorobenzothiazole
- EC Number:
- 210-415-0
- EC Name:
- 2-chlorobenzothiazole
- Cas Number:
- 615-20-3
- Molecular formula:
- C7H4ClNS
- IUPAC Name:
- 2-chloro-1,3-benzothiazole
- Details on test material:
- no purity specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- liver homgenates
Administration / exposure
- Route of administration:
- other: in vitro test
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 30 min
- Frequency of treatment:
- not relevant
- Post exposure period:
- not required
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mg 2-Chlorobenzothiazole/ 3 mL of reaction mixture
Basis:
nominal conc.
- No. of animals per sex per dose:
- not applicable
- Control animals:
- no
- Details on study design:
- In vitro test: control animals not required because enzyme test is calibrated with blancs and standardized solutions
Results and discussion
Any other information on results incl. tables
In the presence of 2 -Chlorobenzothiazole (1 mg/3 mL) in the reaction mix, the degradation of 4 -Dimethylaminoazobenzene, which was used to monitor the potential of rat liver homogenates to metabolize azo dyes, was inhibited by approximately 80 %.
Applicant's summary and conclusion
- Conclusions:
- 2-Chlorobenzothiazole (slightly) inhibits the degradation of the azo dye 4 -Dimethylaminoazobenzene in rat liver homogenates
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