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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 920-632-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: calculation based on classification
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Automatic calculation tool in development at Eurometaux
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: software
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- The potential of the UVCB substance to cause specific target organ toxicity following repeated exposure by oral route was established by classifying the complex metal substance according to rules for classification of mixtures for STOT RE (EU CLP guidance section 3.9.3 pg 382ff). The classification criteria (as set out in EU CLP Annex I: 3.9.3.4.1.) can be used to estimate effects derived from that classification/hazard.
- GLP compliance:
- no
- Remarks:
- other quality assurance
Test material
- Reference substance name:
- Slag, nickel smelting
- IUPAC Name:
- Slag, nickel smelting
- Details on test material:
- Typical across industry as defined in IUCLID 1.2;
See IUCLID Section 1.4, for company specific elemental composition; and representative sample for mineralogical information (IUCLID Section 4.23 -Outotec report)
Constituent 1
Results and discussion
Effect levels
- Dose descriptor:
- conc. level:
- Effect level:
- > 100 mg/kg bw/day (nominal)
- Based on:
- test mat.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The calculated classification via rules for mixtures (Lower Tier) resulted in “STOT repeated : Not classified.
Based on this result, the related criteria provided the estimated dose/concentration value at or below which no significant toxic effects would be observed in a 90-day repeated-dose studyby oral route (see EU CLP Guidance Annex IAnnex 3.9.2.9.7,Table 3.9.3) : Oral(rat), dose concentration >100 mg/kg body weight /day
For more details, see "Human Health classification of C2 nickel slag", attachment in Section7 "Summary record Toxicological information
Applicant's summary and conclusion
- Conclusions:
- Study can be used to predict the single organ toxicity effect by oral route and to determine hazard/classification of the UVCB substance
- Executive summary:
The study provided a conservative estimate of the Single organ toxicity effect, derived on basis of the Classification outcome by applying the rules for mixtures of a Typical (across industry) nickel slag.
It is concluded that slag, nickel smelting is not to be classified for STOT RE. Therefore estimated dose/concentration value at or below which no significant toxic effects would be observed in a 90-day repeated-dose studyis : >100 mg/kg body weight /day
The result is applicable to all nickel slags that fall under the defined concentration ranges (IUCLID section 1.2).
Chemistry of the substance (see IUCLID section 4.23 chemical and mineralogical characterization) shows that nickel slag does contains only minor constituents classified as a STOT RE Cat 1 (Ni compounds) at actual levels 0.15% in typical samples and 0.44%.maximum levels accross industry.
It can be also demonstrated that nickel lag contains minor constituents classified as STOT RE Cat 2 ( ex.Pb compounds) at actual levels <0.02%In vitro measurements of bio-accessibility in solvent that resembles gastric fluid performed according to ASTM D5517.07.(pH 1.5) The fraction of metals that solubilize under these conditions can be considered as worst case determinant of bio-assesability of metals contained in the slag. Results demonstrate low relative bio-accesabilty of metals (Cu 0.04, Ni 0.05, Co 0.06).Dissolved concentrations of Pb and As were below detection limit.
Furthermore, conclusions on bioavailability are supported the physical properties of the substance.
The measurements allowed to demonstrate that the maximum level of bio-accessible NI in nickel slag is 0.02%.
Therefore consideration of reduced bio-accessibility of Ni will further confirm No classification of nickel slags for STOT repeated exposure by oral route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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