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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 920-632-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Automatic calculation tool in development at Eurometaux
Data source
Reference
- Reference Type:
- other: software
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- Acute (inhalation) toxicity of the UVCB substance was determined by deriving classification based on Mixture rules from EU CLP (summation and/or additivity of classified components to derive Hazard class) and back calculation to the corresponding Acute (inhalation) Toxicity criteria.
The classification criteria (as set out in EU CLP Guidance Annex I ) were used to estimate effects. - GLP compliance:
- no
- Remarks:
- other quality assurance
- Test type:
- other: CLP calculation software
Test material
- Reference substance name:
- Slag, nickel smelting
- IUPAC Name:
- Slag, nickel smelting
- Details on test material:
- Typical across industry as in IUCLID Section 1.2
See IUCLID Section 1.4, for company specific elemental composition; and representative sample for mineralogical information (IUCLID Section 4.23 -Outotec report)
Constituent 1
Results and discussion
Effect levels
- Dose descriptor:
- other: Acute toxicity estimate
- Effect level:
- > 5 mg/L air
- Based on:
- test mat.
- Remarks on result:
- other: prediction
Any other information on results incl. tables
The calculated classification via rules for mixtures (additivity, lower Tier) resulted in an "Acute Inhalation: Not classified"(Toxicity of all constituents > 1% w/w is known as of 1st ATP CLP and assessed metals).
Based on this result, the related criteria provided the estimated value for acute (inhalation) toxicity: Acute Toxicity Estimate > 5 mg/l
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Study can be used to predict an ATE and classification of the UVCB substance as a lower tier.
From the resuluts it is concluded that nickel slag is not to be classified for Acute toxicity by the inhalation route. - Executive summary:
The study provided a conservative (lower tier) estimate of the Acute Inhalation toxicity, derived on the basis of Classification outcome (Rules for mixtures) of a typical (across industry) nickel slag: ATE inhalation > 5 mg/l
The result is applicable to all nickel slags that fall under the defined concentration ranges (IUCLID section 1.2).
The result is furthermore supported by (WoE) consideration from chemical & mineralogical information (IUCLID 4.23) showing that Acute toxic species (such as Pb, As, Ni for example) demonstrate low solubility.
Result is further confirmed by extrapolation from oral to inhalation route based on worst case 100% absorption rate.
Using ATE oral: 2000 mg/kg bw and the extrapolation formula 1mg/kgbw = 0.0052 mg/l/4h, the inhalation ATE will be 10.4mg/l/4h
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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