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EC number: 692-448-4 | CAS number: 170621-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 - 17 Apr 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Version / remarks:
- 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Chinese National Environmental Protection Agency, the Guidelines for the Testing of Chemicals, 2004, 207 Earthworm, Acute Toxicity Test
- Version / remarks:
- 2004
- GLP compliance:
- no
- Remarks:
- according to Chinese GLP (GB/T 22275.1-2008); comparable to OECD GLP C(97)186/FINAL
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on preparation and application of test substrate:
- - Method of mixing into soil (if used): Since the test substance is insoluble in water and suitable solvents, it was directly applied and mixed in silicia sand after weighting with a balance. The treated sand was mixed thoroughly with artificial soil and then was moistured with deionized water to obtain an equal distribution of the test substance in the test substrate
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: earthworm
- Source: Shanghai Yinquan Agriculture Development Co., Ltd
- Age at test initiation (mean and range, SD): adult (with citellum)
- Weight at test initiation (mean and range, SD): 300 - 600 mg
- The newly acquired earthworms were quarantined and observed for 14 day prior to testing
- Earthworms were bred in cow dung and kept in uncontaminated artificial soil under 20 °C for 7 days prior testing - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- Initial: 20.2 °C
End: 20.7 °C - pH:
- Initial: 6.15
End: 6.17 - Moisture:
- Initial: 30.87% dry soil weight
End: 29.57% dry soil weight - Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 1 L glass beakers covered with a film to avoid drying-out
- Amount of soil or substrate: 750 g
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
OTHER TEST CONDITIONS
- Photoperiod: continuous light
- Light intensity: 600 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): The number of dead and affected worms was observed at 7 and 14 day after test start.
TEST CONCENTRATIONS
- Range finding study:
- Test concentrations: 10, 100 and 1000 mg/kg soil dw
- Results used to determine the conditions for the definitive study: no mortality at any of the test concentrations - Nominal and measured concentrations:
- control and 1000 mg/kg dw soil (nominal)
- Reference substance (positive control):
- yes
- Remarks:
- Chloroacetamide
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality at end of exposure period: no mortality occurred
- Total mass of adults at beginning of test: control: 1670 mg; 1000 mg/kg: 1590 mg
- Total mass of adults at end of test: control: 1610 mg; 1000 mg/kg: 1570 mg - Results with reference substance (positive control):
- LC50 (14d) = 10.82 mg/kg dw (CI: 9.75 - 11.99 mg/kg dw)
Test performed 6 - 20 Sep 2012 - Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- non GLP study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO guideline 10872:2020
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on preparation and application of test substrate:
- - Method of mixing into soil (if used): 4 g of dry soil were thoroughly mixed in 10-ml glas jars with the respective mass of test item
- Controls: Lufa St. 2.2 soil without test item - Test organisms (species):
- Caenorhabditis elegans
- Animal group:
- nematods
- Details on test organisms:
- TEST ORGANISM
- Common name: nematode
- Source: Caenorhabditis Genetic Centre, University of Minnesota
- Age at test initiation: J1 juvenile stages - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 19.5 – 20.5 °C;
- pH:
- 5.4 (± 0.1)
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 24-well multidishes
- Amount of soil or substrate: 4 g
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 8 (soil test 1), 6 (soil test 2)
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Soil classification system: loamy sand
- Composition (if artificial substrate): Particle size distribution: <0.002 mm: 6.4 (± 0.9) %; 0.002-0.05 mm: 12.2 (± 0.6) %; 0.05-2.0 mm: 81.4 (± 1.2) %
- Organic carbon (%): 2.16 % (± 0.40)
- Maximum water holding capacity: 44.8 (± 5.0) g/100 g
OTHER TEST CONDITIONS
- Photoperiod: in the dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : growth adn reproduction after 96 hours of exposure
- Nominal and measured concentrations:
- 640, 1600, 4000, 10000, 25000, 50000 mg/kg dry material (nominal)
- Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 25 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 4 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 96 h
- Dose descriptor:
- EC10
- Effect conc.:
- 1 824 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 16 582 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- - No. of offspring produced: ≥192 (control), ≥ 34 (treatment)
- Reported statistics and error estimates:
- The data analysis was performed with one-way ANOVA (post-hoc test: Dunnett, Games-Howell), descriptive statistics, dose-response curves fitted to %inhibition data of growth and reproduction.
Referenceopen allclose all
Description of key information
LC50 (14d) > 1000 mg/kg soil dw (OECD 207, Eisenia fetida)
EC10 (96h) = 1824 mg/kg soil dw (ISO 10872:2020, Caenorhabditis elegans)
Key value for chemical safety assessment
Additional information
One study is available on the short-term toxicity of Aluminum magnesium vanadium oxide to soil macroorganisms (2013). This study was conducted as a limit test according to OECD Guideline 207 and Chinese GLP. The test organism Eisenia fetida was exposed to the single test concentration of 1000 mg/kg dw in artificial soil. No mortality occurred and the LC50 was > 1000 mg/kg soil dw.
One supporting study is available on the long-term toxicity of Aluminum magnesium vanadium oxide to soil macroorganisms (2020). This study was not conducted under GLP conditions according to ISO Guideline 10872:2020. The test organism Caenorhabditis elegans was exposed to the test concentrations of 640, 1600, 4000, 10000, 25000, 50000 mg/kg dw in artificial soil. The NOEC based on growth and reproduction were determined to be≥25000 and 4000 mg/kg dws, respectively. The EC10 based on growth was determined to be 1824 mg/kg dws.
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