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EC number: 692-448-4 | CAS number: 170621-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 31 Jan - 22 Apr 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Version / remarks:
- 2008
- GLP compliance:
- no
- Remarks:
- according to Chinese GLP (GB/T 22275.1-2008); comparable to OECD GLP C(97)186/FINAL
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: All concentrations, samples from frshly prepared and aged media
- Sampling method: One vessel was selected randomly and one 10 mL samples was taken
- Sample storage conditions before analysis: The samples, which were not analyzed within 24 h after sampling, were stored at 5 ± 3 °C - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Loading rates of 0.160, 0.340, 0.800, 1.70, 3.60 and 8.00 mg/L were prepared by stirring (via magnetic stirrer) in the dark at 700 rpm for 72 h. The media were then filtered by using a 0.45 μm nitrocellulose membrane. The filtrates were stored at room temperature.The filtrate was directly used as the test solution.
- Differential loading: yes - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea
- Source: in-house culture; originally obtained from MicroBioTests Inc (ID: DM-MBT-121126)
- Age of parental stock: < 24 hours old
- Feeding during test: yes
- Food type: concentrated freshwater suspensions of unicellular green algae Desmodesmus Subspicatus and Pseudokirchneriella subcapitata
- Amount: at a rate equivalent to 0.1- 0.2 mg of organic carbon per adult per day
- Frequency: daily - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- 140 - 175 mg/L as CaCO3
- Test temperature:
- 19.4 - 20.3 °C
- pH:
- 7.03 - 7.90
- Dissolved oxygen:
- 8.03 - 9.14 mg O2/L
- Nominal and measured concentrations:
- control, 0.160, 0.340, 0.80, 1.70, 3.60 and 8.00 mg/L (nominal, loading rate)
Measured concentrations see tables in Any other information on materials and methods field - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, fill volume: 75 mL glass vessels containing approximately 60 mL of the test medium
- Renewal rate of test solution (frequency): on days 2, 4, 7, 9, 11, 14, 16 and 18
- No. of organisms per vessel: 1
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
- Culture medium different from test medium: No
- Intervals of water quality measurement: Oxygen concentration temperature, hardness and pH values were measured twice a week, in the fresh and aged test medium of the control(s) and the highest test substance concentration
OTHER TEST CONDITIONS
- Adjustment of pH: yes (to pH 7 by using 2 mol/L HCl for 10 mol/L NaOH
- Photoperiod: 16 hours light and 8 hours dark
- Light intensity: 1200 lux
EFFECT PARAMETERS MEASURED: reproduction and mortality were recorded five to seven times per week - Reference substance (positive control):
- no
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOELR
- Effect conc.:
- 0.16 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- loading rate
- Basis for effect:
- reproduction
- Remarks on result:
- other: (corresponding to the time-weighted mean measured concentrations of Al, V and Mg of 0.00833, 0.00213 and 8.64 mg/L)
- Duration:
- 21 d
- Dose descriptor:
- LOELR
- Effect conc.:
- 0.34 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- loading rate
- Basis for effect:
- reproduction
- Remarks on result:
- other: (corresponding to the time-weighted mean measured concentrations of Al, V and Mg of 0.00821, 0.00320 and 8.48 mg/L);
- Duration:
- 21 d
- Dose descriptor:
- EL50
- Effect conc.:
- 3.71 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- loading rate
- Basis for effect:
- reproduction
- Remarks on result:
- other: 95% confidence limits: was 1.83-54.4 mg/L
Reference
Table 1: Mortalities of parent animals
Day |
Control |
Loading rate [mg/L] |
|||||
0.160 |
0.340 |
0.800 |
1.70 |
3.60 |
8.00 |
||
2d |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
4d |
0 |
0 |
0 |
0 |
0 |
0 |
4 |
7d |
0 |
0 |
1 |
0 |
0 |
0 |
0 |
9d |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
11d |
0 |
0 |
0 |
0 |
0 |
0 |
3 |
13d |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
17d |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
18d |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
21d |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
Cumulative adult mortalities |
0 |
0 |
1 |
0 |
0 |
1 |
10 |
Mortality(%) |
0 |
0 |
10 |
0 |
0 |
10 |
100 |
Table 2: Number live offspring:
Loading rate [mg/L] |
Cumulative No. of offspring after 21 days |
Parallel group |
|||||||||
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
||
Control |
Total |
107 |
102 |
98 |
127 |
94 |
108 |
101 |
134 |
93 |
103 |
0.160 |
Total |
122 |
100 |
115 |
108 |
104 |
104 |
99 |
102 |
99 |
109 |
0.340 |
Total |
M |
88 |
67 |
50 |
52 |
68 |
87 |
70 |
62 |
60 |
0.800 |
Total |
100 |
95 |
92 |
83 |
88 |
95 |
80 |
90 |
73 |
77 |
1.70 |
Total |
71 |
70 |
65 |
67 |
58 |
68 |
73 |
82 |
59 |
68 |
3.60 |
Total |
67 |
30 |
65 |
49 |
60 |
38 |
M |
57 |
53 |
41 |
8.00 |
Total |
M |
M |
M |
M |
M |
M |
M |
M |
M |
M |
M:Mortality of parent
Description of key information
NOELR (21 d) = 0.160 mg/L (nominal, loading rate) (OECD 211, Daphnia magna). Corresponding to the time-weighted mean measured concentrations of Al, V and Mg of 0.00833, 0.00213 and 8.64 mg/L, respectively
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.16 mg/L
Additional information
A semi-static test design according to OECD 211 was chosen in a study according to Chinese GLP to evaluate the chronic toxicity of aluminium magnesium vanadium oxide to freshwater invertebrates at nominal concentrations from 0.16 mg/L to 8.00 mg/L (2013). The substance has a low water solubility and therefore the test solution was prepared by adding the appropriate test item to the dilution water. After stirring for 72 hours the resulting solution was filtrated through 0.45 µm filters. Following this, the filtrates were used for the main test without dilution. The test solutions included the dilution water control and nominal concentrations of 0.160, 0.340, 0.800, 1.70, 3.60 and 8.00 mg/L test item. Each treatment concentration was prepared separately. The average recoveries of 0.0200 mg/L and 0.160 mg/L Al-spiked samples were 108% and 94.3% with RSDs of 6.46% and 1.29%, and the average recoveries of 0.0200 mg/L and 0.160 mg/L V-spiked samples were 97.3% and 96.8% with RSDs of 0.28% and 1.05%, and the average recoveries of 15 mg/L and 30 mg/L Mg-spiked samples were 106% and 91.9% with RSDs of 5.99% and 5.02%.
The 21 days NOELR was determined to be 0.160 mg/L (corresponding to the time-weighted mean measured concentrations of Al, V and Mg of 0.00833, 0.00213 and 8.64 mg/L). The 21 days LOELR value was determined to be 0.340 mg/L (corresponding to the time-weighted mean measured concentrations of Al, V and Mg of 0.00821, 0.00320 and 8.48 mg/L). The 21 days EL50 value was 3.71 mg/L (95% confidence limits: 1.83-54.4 mg/L).
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