Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 229-129-2 | CAS number: 6416-66-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The 12th of October, 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- adopted 27.07.95
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- photometric method
- Type:
- Pow
- Partition coefficient:
- ca. 0.025
- Temp.:
- 20 °C
- pH:
- ca. 6.83
- Type:
- log Pow
- Partition coefficient:
- ca. -1.609
- Temp.:
- 20 °C
- pH:
- 6.83
- Details on results:
- A first scan of the solutions was performed in the range 190 – 800 nm to choose the best wavelength peak for the quantitative measurements. In the case of Acid Red 249: l= 311.50 nm.At 48 hours was not reached the equilibrium, and new determinations after 96 hours were done. At 96 hours values reached equilibrium, so this value was considered for final calculations.
- Conclusions:
- The average Pow measured is 0.0253 at pH of 6.83, the average log Pow measured is - 1.6090.
- Executive summary:
Partition coefficient was determined by OECD Guideline 107 (Partition Coefficient (n-octanol/water), Shake Flask Method), adopted 27.05.95.
n- octanol and double distilled water were pre saturated: enough quantity of double distilled water was mixed with n-octanol at room temperature and kept under agitation during 24 hours, then allowing phase separation. Analogous procedure was followed for n-octanol with addition of double distilled water.
Approximately exactly 0.04 g test sample was weighed and dissolved with double distilled water saturated in n-octanol to 100 ml in a volumetric flask (mother solution). pH was recorded.
The average Pow measured is 0.0253 at pH of 6.83, the average log Pow measured is - 1.6090 at 20°C.
Reference
Description of key information
- 1.6090
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.609
- at the temperature of:
- 20 °C
Additional information
Partition coefficient was determined by OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method), adopted 27.05.95.
n- octanol and double distilled water were pre saturated: enough quantity of double distilled water was mixed with n-octanol at room temperature and kept under agitation during 24 hours, then allowing phase separation. Analogous procedure was followed for n-octanol with addition of double distilled water.
Approximately exactly 0.04 g test sample was weighed and dissolved with double distilled water saturated in n-octanol to 100 ml in a volumetric flask (mother solution). pH was recorded.
The average Pow measured is 0.0253 at pH of 6.83, the average log Pow measured is - 1.6090 at 20°C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
