Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 401-280-0 | CAS number: 91273-04-0 CM 23-376; REOMET 30
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April - May 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Version / remarks:
- 1981
- Deviations:
- yes
- Remarks:
- The volume of the test solution was reduced to 1.5 litre
- GLP compliance:
- no
- Remarks:
- but GLP like quality assurance
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge:
Bacteria collected from activated sludge of the sewage treatment plant of CH-4153 Reinach on 15/04/85. The preparation was carried out according to the method described in the guideline. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 10 mg/L
- Based on:
- test mat.
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium:The test medium was prepared according to the method described in the guideline.
- Test temperature: 22 + or - 2 degrees
- Aeration of dilution water: Approx. 50 ml/min free of carbon dioxide.
TEST SYSTEM
- Culturing apparatus: 2 liters flasks equipped with gas inlet and magnetic stirrer.
- Number of culture flasks/concentration: 1
SAMPLING
- Sampling frequency: day 6, 9, 13, 17, 20, 23, 27, 28 - Reference substance:
- aniline
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 5
- Sampling time:
- 28 d
- Remarks on result:
- other: 20 mg/L test substance
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 9
- Sampling time:
- 28 d
- Remarks on result:
- other: 10 mg/L test substance
- Details on results:
- The test item is not is not biodegradable in this test.
The biodegradation of the reference substances was calculated as 84% in 28 days - Interpretation of results:
- not readily biodegradable
- Conclusions:
- The key study (Ciba, 1985) was performed according to OECD guideline no. 301B (1981). The relative degradation values calculated from the measurements performed during the test period (28 days) revealed no significant degradation of the test item. At 10 mg/L and 20 mg/L, 9 % and 5% were transformed to carbon dioxide, respectively. No toxicity control was included in this test, but test item is inhibitory to sludge bacteria (EC20 = 38 mg/L). In a supportive study (Ciba, 2005) the Chemical Oxygen Demand was determined. After an exposure of 2 h the amount of CO2 was very low, indicating no degradation of the test item. The substance EC 401-280-0 hydrolyses in contact with water immediately.
Therefore the hydrolysis products need to be considered.
Reference
Description of key information
Parent substance EC 401 -280-0
The key study (Ciba, 1985) was performed according to OECD guideline no. 301B (1981). The relative degradation values calculated from the measurements performed during the test period (28 days) revealed no significant degradation of the test item. At 10 mg/L and 20 mg/L, 9 % and 5% were transformed to carbon dioxide, respectively. No toxicity control was included in this test, but test item is inhibitory to sludge bacteria (EC20 = 38 mg/L).
In a supportive study (Ciba, 2005) the Chemical Oxygen Demand was determined. After an exposure of 2 h the amount of CO2 was very low, indicating no degradation of the test item. The substance EC 401-280-0 hydrolyses in contact with water immediately.
Therefore the hydrolysis products were also considered.
Hydrolysis products:
bis(2 -ethylhexyl)amine
Based on a weight-of-evidence approach,di-(2-ethylhexyl)amine is considered to be moderately biodegradable (not readily biodegradable according to OECD criteria). Two results from ready biodegradability tests are available, both performed under GLP conditions according to OECD 301B (CO2 Evolution Test), but indicating different biodegradation potential. In the most recent study and based on CO2/ThCO2, no biodegradation was observed, even after prolonged exposure of 60 days in total (BASF, 2012). Based on DOC removal, 83% of the substance was eliminated after 28 days, which is, however, interpreted to be likely due to adsorption to the sludge and/or test vessels. In the older study and based on CO2/ThCO2, the substance was degraded by ca. 30 % after 28 days and by ca. 50% after 39 days, respectively (BASF, 1997). The latter result is supported by a Zahn-Wellens-Test performed according to an older protocol, but similar to OECD 302B. The substance was easily eliminated from water (93% after 15 days, based on COD) (Hoechst, 1977). Furthermore, two QSAR results support the potential for biodegradation ofdi-(2-ethylhexyl)amine.With the CATALOGIC model simulating the MITI (I)-Test (OECD 301C), the degradation was estimated to reach ca. 39 % after 28 days (BASF, 2011). With the BIOWIN v4.10 model of the US EPA EPISuite (v4.10) programme, several of the seven BIOWIN sub-models predict the substance to be rapidly degradable within days or weeks. The overall prediction of ready biodegradability is "no", but on average the sub-models indicate that the substance is moderately biodegradable (BASF, 2013).
1H-1,2,4 -Triazole
Data on1H-1,2,4-triazole show that the substance is not readily biodegradable (ECHA disseminated REACH dossier, 2014)
Formaldehyde
Formaldehyde is expected to be readily biodegradable at low concentrations (Gerike 1990).
Key value for chemical safety assessment
- Biodegradation in water:
- not biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.