Registration Dossier
Registration Dossier
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EC number: 640-001-9 | CAS number: 958445-54-0
Endpoint summary
Administrative data
Description of key information
Additional information
Test results for ADONA, the ammonium salt, are also reported for MeDONA. ADONA exists in dissociated form, as ammonium and DONA anion, in aqueous solution. The hydrolysis half-life of MeDONA in pure water and ambient temperature was determined to be 2.68 ± 1.63 minutes. The hydrolysis products are methanol and DONA free acid. MeDONA will therefore not exist for more than a few minutes in aqueous solution, being converted totally to methanol and DONA in any environmental system. Methanol is a REACH-registered substance and is not considered further. Given a pKa ca. 2, DONA free acid will exist as the anion under environmentally relevant conditions. Biodegradation testing of ADONA was conducted using an OECD guideline 301B. Since this test measures evolution of carbon dioxide, it would detect potential biotransformation of DONA anion and cannot detect biotransformation of ammonium. Therefore, the ADONA biodegradation result is directly applicable to MeDONA. In the BCF and Koc tests, DONA was the only analyte monitored. Both tests were conducted at pH ca. 7, which would maintain DONA in anionic form. Because these two tests, if done using MeDONA as the starting material, would also be conducted at near-neutral pH, results of the ADONA tests are directly applicable to MeDONA.
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