Registration Dossier
Registration Dossier
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EC number: 640-001-9 | CAS number: 958445-54-0
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- January 18, 2008 - January 24, 2008
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Test substance is hydrolytically unstable; water solubility test is not feasible.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test substance was prepared in 1 wt% in water and saturated sample was analyzed by GC with an Electron Capture Detector.
- GLP compliance:
- no
- Type of method:
- other: capillary gas chromatography
Test material
- Reference substance name:
- MeDONA
- IUPAC Name:
- MeDONA
- Details on test material:
- - Name of test material (as cited in study report): MeDONA
- Substance type: single-constituent substance
- Physical state: Clear and colorless liquid
- Analytical purity: 98.9%
- Purity test date: 2/17/2009
- Lot/batch No.:NB 140499-21-8
- Expiration date of the lot/batch :08/25/2014
- Stability under test conditions: Stable
- Storage condition of test material: Frozen
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 4.38 mg/L
- Details on results:
- The water solubility of MeDONA in water was determined to be 4.38 mg/L at 23 °C. Only one sample was prepared and analyzed.
Any other information on results incl. tables
The pH of 1% MeDONA solution is 5.3±0.3.
Applicant's summary and conclusion
- Conclusions:
- MeDONA had a water solubility of 4.38 mg/L at 23 °C.
- Executive summary:
The water solubility of MeDONA in water was prepared in 1 wt% in water and shaken for one hour. The saturated sample was centrifuged and the clear aqueous phase was analyzed by GC/ECD. MeDONA had a water solubility of 4.38 mg/L at 23 °C from a single measurement. Since MeDONA has a hydrolytic half-life of 2.68±1.63 minutes in neutral water and a half life of 52.5 ± 1.99 minutes at pH 2 water. As such, experimental measurement of water solubility is not feasible. Therefore, this data is considered not reliable.
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