Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 940-284-1 | CAS number: 1591782-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Due to its surfactant properties and in line with OECD test guidelines, the potential contact hypersensitivity of Glucamide 810 (Test material E185/2012 PC W; 85.5%) was assessed in guinea pig maximization test according to Magnusson and Kligman (OECD TG 406). After intradermal induction using a 0.5 % (w/v) test concentration (vehicle water), dermal induction and challenge treatment was performed with a 5% (w/v) test concentration. No skin reactions occurred after challenge exposure (sensitization rate = 0%) indicating that Glucamide 810 is not a skin sensitizer.
The same conclusion was reached for the read-across compound Glucamide 24 which supports a.m. result. Using OECD TG 406 (1981, Modified Buehler, Test material E-4086.01, 45% active gel adjusted for a.i.) as well as the guinea pig maximization test according to Magnusson and Kligman following OECD TG 406 (1992, Test material 10000506, 96.7%), Glucamide 24 was not a skin sensitizer.
Migrated from Short description of key information:
The registered substance does not induce any signs of skin sensitization in animals when evaluated in the guinea pig maximization test according to OECD TG 406. The sensitization incidence was 0%.
Justification for selection of skin sensitisation endpoint:
Guideline study according to GLP. No derivations and/or confounders. Klimisch rating 1 representing reliability without restrictions. Information is valid and meet data requirements.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
The registration substance is not a skin sensitizer. Also no sensitizing potential was revealed for structural and biological close analogues. None of the available toxicological data and known exposure conditions indicates concern that Glucamide 810 may possess respiratory sensitization properties.
Migrated from Short description of key information:
The registration substance is not a skin sensitizer. Also no sensitizing potential was revealed for structural and biological close analogues. None of the available toxicological data and known exposure conditions indicates concern that it may pose a respiratory sensitization risk.
Justification for classification or non-classification
Based on all available data the registered substance is not a skin sensitiser and therefore is not subject for classification and labelling requirements with regard to this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.