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EC number: 940-284-1 | CAS number: 1591782-62-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No data are available on the absorption, distribution, metabolism or elimination (ADME) of Glucamide 810. However, based on the close structural similarity and generally comparable metabolic pathway, data can be read across from data generated on Glucamide 24. For this compound, oral absorption was greater 80% over a 72 hour period with more than 99% excreted urine. No bioaccumulation potential was detected. Dermal absorption was below 1% over a 72 hour test period and thus negligible.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 80
- Absorption rate - dermal (%):
- 1
Additional information
No data are available on the absorption, distribution, metabolism or elimination (ADME) of Glucamide 810. However, based on the close structural similarity and common metabolic pathway, data can be read across from data generated on Glucamide 24.
After oral application, the absorption, distribution, metabolism and excretion (ADME) of radiolabeled n-lauryl-glucose amide ([14C]-C12-G5 Base (Glucamide 24, radioactive purity 99.1%) was investigated in fasted male Sprague-Dawley rats (4 in total). Following oral administration of 150 mg/kg bw dose in ethanol:water (20:80), 79.7%, 16.03%, 0.31% and 0.18% of radioactivity was recovered in the urine (plus cage wash), feces (plus gastrointestinal tract wash), expired CO2, and tissue plus carcass, respectively, at the end of 72 hours with the largest amount of radioactivity collected in the 8-24 hour test period. Individual tissue distribution at 72 hours indicated that the highest levels in the liver (16x plasma radioactive content) followed by kidneys, spleen, carcass, lungs and gastrointestinal tract. All other tissues were ≤ 3x background. Based on these data oral absorption was estimated to be 80% over the 72-hour period with > 99% of excreted in the urine and 0.3% eliminated in expired CO2with only 0.2% in the tissues and carcass. The assessment of billiary elimination was beyond the scope of the study.
After dermal application, the ADME of radiolabeled n-lauryl-glucose amide ([14C]-C12-G5 Base; radiochemical purity 99.8%) was investigated in fasted male Sprague-Dawley rats. Following dermal administration of 9.9 mg/kg bw (0.26 mg/cm2) dose in ethanol, the material balance was 95 ± 5.0% (n=2). At the end of testing (72-hours), 94.4% of radioactivity was recovered at the test site skin (plus dose cell wash), 0.27% in the urine (plus cage wash), 0.19% tissue (plus carcass), 0.1% in the feces (plus gastrointestinal tract wash), and 0.02% in expired CO2. Individual tissue distribution at 72 hours indicated low levels in all tissues with the highest levels in the femur (20x plasma radioactive content) followed by carcass, whole blood, adipose and bone marrow. All other tissues were ≤ 5x background. Based on these data dermal absorption was estimated to be <1% over a 72 hour test period, with the principal route of elimination being urine. The assessment of billiary elimination was beyond the scope of the study.
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