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EC number: 939-368-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
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- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
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- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin: similar to OECD 404 guideline study, rabbits, exposure for 4h under occlusive dressing: slightly irritating but no classification is required.
Eye: similar to OECD 405 guideline study, rabbits, persistence of eyes damages at the end of the observation period (7 days).
Respiratory tract: signs of irritation of the respiratory tract in the acute inhalation study (see 7.2.2 Ac. inhalation tox V1 2013 CitoxLab) and reporting of respiratory irritation cases in Human (see 7.10.5 exposure related observation in humans: manufacturing plant)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 11 March 1994 to 29 June 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is sufficiently documented. No certificate of analysis is available.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: New Zealand Albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS:
- Source: Animals were received from Ace Animals on 1/18, 2/15 and 2/22/94.
- Age at study initiation: The animals were born the week of 10/24 through 12/12/93.
- Weight at study initiation: 2.2 - 2.7 kg
- Housing: The animals were housed 1/cage in suspended cages. Bedding was placed beneath the cages and changed at least three times/week.
- Diet (e.g. ad libitum): Fresh Purina Rabbit Chow (Diet # 5321)
- Water (e.g. ad libitum): Water was available ad libitum.
- Acclimation period: three days
ENVIRONMENTAL CONDITIONS:
- Temperature (°C): No data on temperature but the animal room was temperature controlled.
- Humidity (%): data not available
- Air changes (per hr): data not available
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle
IN-LIFE DATES: data not available - Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped free of hair, intact or abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Test material: Amount applied: 0.5 g/site (dry weight of the test article). The test article was moistened with distilled water (made pasty) after application .
pH: data not available - Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- At 3 min, 1, 4, 24, 48, 72 hours and on day 7 after patch removal
- Number of animals:
- 3
- Details on study design:
- TEST SITE:
- Area of exposure: disk of ca. 2-3 cm of diameter
- % coverage: data not available
- Type of wrap if used: two 2.5 cm square gauze patch which were secured with adhesive tape. The torso was wrapped with plastic and secured with adhesive tape.
REMOVAL OF TEST SUBSTANCE:
- Washing: any residual test article was washed off with distilled water prior to dermal observations.
- Time after start of exposure: 4 hours
SCORING SYSTEM: according to Draize
- Erythema and Eschar Formation:
No erythema -> 0
Very slight erythema (barely perceptible) ->1
Well defined erythema -> 2
Moderate to severe erythema -> 3
Severe erythema (beef redness) to eschar formation preventing grading of erythema -> 4
- Oedema Formation:
No oedema -> 0
Very slight oedema (barely perceptible) -> 1
Slight oedema (edges of area well defined by definite raising) -> 2
Moderate oedema (raised approximately 1 mm) -> 3
Severe oedema (raised more than 1 mm and extending beyond area of exposure) -> 4
- Primary Dermal Irritation Index = (Sum of individual Erythema scores + Sum of individual Edema scores) / 12 - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 1.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: intact skin. Mean scores over 24, 48 and 72 hours for each animal were 0.0, 0.33 and 1.7.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 0 - <= 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Remarks on result:
- other: intact skin. Mean scores over 24, 48 and 72 hours for each animal were 0.0, 0.33 and 1.0.
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1.17
- Max. score:
- 8
- Reversibility:
- fully reversible within: 72 hours or 7 days
- Remarks on result:
- other: scarified and intact skin
- Irritant / corrosive response data:
- Erythema, absent at 3 minutes post dose, was absent to slight at one and four hours. At 24 and 48 hours after patch removal, erythema was absent to well defined. At 72 hours erythema was absent to slight and absent on day 7. Edema, absent at 3 minutes post dose, was absent to slight at one and four hours. At 24 hours after patch removal, edema was absent to well defined. Edema was absent to slight at 48 hours and absent at 72 hours and on day 7. The modified primary irritation index is 1.17.
SEE INDIVIDUAL SCORES IN TABLE 1 BELOW - Other effects:
- There were no signs of systemic toxicity noted during the observation period.
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information The test chemical was considered as slightly irritating and no classification according to EU criteria is required. Criteria used for interpretation of results: EU
- Conclusions:
- Under the experimental conditions of this study, the test item was slightly irritant when applied topically to rabbits. However, according to the classification criteria laid down in Council Directive 67/548/EEC (and subsequent adaptations), the test item reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda should not be classified as irritating to the skin.
- Executive summary:
In a primary dermal irritation study (1994), New Zealand Albino rabbits (3 animals) were dermally exposed to 0.5 g of undiluted test article. Intact and abraded test sites were covered with an occlusive dressing for 4 hours. Skin sites were then scored for erythema and oedema 3 min, 1 hour, 4, 24, 48, 72 hours and day 7 after patch removal. Irritation was scored by the method of Draize.
Erythema, absent at 3 minutes post dose, was absent to slight at one and four hours. At 24 and 48 hours after patch removal, erythema was absent to well defined. At 72 hours erythema was absent to slight and absent on day 7. Edema, absent at 3 minutes post dose, was absent to slight at one and four hours. At 24 hours after patch removal, edema was absent to well defined. Edema was absent to slight at 48 hours and absent at 72 hours and on day 7.
Mean scores over 24, 48 and 72 hours for each animal were 0.0, 0.33 and 1.7 for erythema and 0.0, 0.33 and 1.0 for edema. Similar effects were observed with abraded skin. The modified primary irritation index is 1.17.
Under the experimental conditions of this study, the test item was slightly irritant when applied topically to rabbits. Based on these results, the test item reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda is not classified as irritating to the skin according to Annex VI of the Directive 67/548/CEE and to EU Regulation 1272/2008 (CLP).
Reference
Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Score at time point / Reversibility |
Erythema |
Edema |
||
Max. score: 4 |
Max. score: 4 |
|||
normal |
scarified |
normal |
scarified |
|
3 min |
0 / 0 / 0 |
0 / 0 / 0 |
0 / 0 / 0 |
0 / 0 / 0 |
1 hr |
0 / 0 / 1 |
1 / 0 / 0 |
0 / 0 / 1 |
0 / 0 / 0 |
4 hrs |
0 / 0 / 0 |
0 / 0 / 0 |
0 / 0 / 0 |
0 / 0 / 1 |
24 hrs |
0 / 1 / 2 |
1 / 0 / 2 |
0 / 1 / 2 |
1 / 0 / 2 |
48 hrs |
0 / 0 / 2 |
0 / 0 / 2 |
0 / 0 / 1 |
1 / 0 / 1 |
72 hrs |
0 / 0 / 1a |
0 / 0 / 1a |
0 / 0 / 0 |
0 / 0 / 0 |
7 days |
0 / 0 /0f |
0 / 0 /0f |
0 / 0 / 0 |
- |
Average 24h, 72h |
0.0 /0.33/ 1.7 |
0.33/ 0.0 /1.7 |
0.0 /0.33/ 1.0 |
0.66 / 0.0 / 1.0 |
Reversibility*) |
c. |
c. |
c. |
c. |
Average time (unit) for reversion |
7 days |
7 days |
72 h |
72 h |
*) Reversibility: c. = completely reversible;n.c.= not completely reversible; n. = not reversible
a = skin appeared dry
f = flaking skin
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 11 March 1994 to 29 June 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study is sufficiently documented. No certificate of analysis is available.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- other: New Zealand Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS:
- Source: Animals were received from Ace Animals on 1/18, 2/15 and 2/22/94.
- Age at study initiation: The animals were born the week of 10/24 through 12/12/93.
- Weight at study initiation: 2.2 - 2.7 kg
- Housing: The animals were housed 1/cage in suspended cages. Bedding was placed beneath the cages and changed at least three times/week.
- Diet (e.g. ad libitum): Fresh Purina Rabbit Chow (Diet # 5321)
- Water (e.g. ad libitum): Water was available ad libitum.
- Acclimation period: three days
ENVIRONMENTAL CONDITIONS:
- Temperature (°C): No data on temperature but the animal room was temperature controlled.
- Humidity (%): data not available
- Air changes (per hr): data not available
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle
IN-LIFE DATES: data not available - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL:
- Amount applied (volume or weight with unit): 0.1 ml equivalent of test material introduced into the conjunctival sac of the each eye
- Concentration (if solution): not applicable
- pH: no applicable
VEHICLE: / - Duration of treatment / exposure:
- Single conjunctival instillation
- Observation period (in vivo):
- 1 hour, and days 1, 2, 3 and 7 after the instillation
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing : 20-30 seconds after instillation of the test article, the left eye of each rabbit was flushed for one minute with lukewarm water. The right eye of each animal remained unwashed.
SCORING SYSTEM: The eyes were examined and scored by the Draize technique at 1 hour post dose and again on days 1, 2, 3 and 7 post dose.
TOOL USED TO ASSESS SCORE: data not available - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 1.33 - <= 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Unwashed: Mean scores calculated for each animal over 24, 48 and 72 hours were 2.0, 1.33 and 1.33 for corneal opacity.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks:
- at day 7
- Remarks on result:
- other: Unwashed: Mean scores calculated for each animal over 24, 48 and 72 hours were 1.0, 1.0 and 1.0 for iris lesions.
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 2 - <= 2.7
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- at day 7 for 1 animals
- Remarks on result:
- other: Unwashed: Mean scores calculated for each animal over 24, 48 and 72 hours were 2.7, 2.0 and 2.0 for redness of the conjunctiva
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- >= 2.33 - <= 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: Unwashed: Mean scores calculated for each animal over 24, 48 and 72 hours were 3.0, 2.33 and 3.0 for chemosis.
- Irritant / corrosive response data:
- Unwashed: Corneal opacity, noted in 3/3 eyes, persisted up to day 7. Iritis, noted in 3/3 eyes, cleared by day 7. Moderate conjunctival irritation, noted in 3/3 eyes, persisted up to day 7 in one eye and improved to slight in two eyes.
Washed: Corneal opacity was noted in two eyes on day 7. Iritis, noted in 3/3 eyes, persisted up to day 7 in one eye. Moderate conjunctival irritation, noted in 3/3 eyes, persisted up to day 7 in one eye, cleared in one eye and improved to slight in the third eye. - Other effects:
- There were no signs of systemic toxicity noted during the observation period.
- Interpretation of results:
- highly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the experimental conditions of this study, the test item was found severely irritating to the eye of rabbit. Based on these results, the test item reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda is classified Xi, R 41, risk of serious damage to eyes, according to Annex VI of the Directive 67/548/CEE, and Eye Damage Cat 1, H318 according to EU Regulation 1272/2008 (CLP), considering the persistence of eye damages at the end of the observation period (7 days).
- Executive summary:
In a primary eye irritation study (1994), 0.1 ml equivalent of the test article was instilled into the conjunctival sac of each eye of New Zealand Albino rabbits (3 animals). 20-30 seconds after instillation of the test article, the left eye of each rabbit was flushed for one minute with lukewarm water. The right eye of each animal remained unwashed. Animals were then observed for 7 days. Irritation was scored by the method of Draize.
For unwashed eyes : Corneal opacity, noted in 3/3 eyes, persisted up to day 7. Iritis, noted in 3/3 eyes, cleared by day 7. Moderate conjunctival irritation, noted in 3/3 eyes, persisted up to day 7 in one eye and improved to slight in two eyes.
Mean scores calculated for each animal over 24, 48 and 72 hours were 2.0, 1.33 and 1.33 for corneal opacity; 1.0, 1.0 and 1.0 for iris lesions; 2.7, 2.0 and 2.0 for redness of the conjunctiva and 3.0, 2.33 and 3.0 for chemosis.
For washed eyes: Corneal opacity was noted in two eyes on day 7. Iritis, noted in 3/3 eyes, persisted up to day 7 in one eye. Moderate conjunctival irritation, noted in 3/3 eyes, persisted up to day 7 in one eye, cleared in one eye and improved to slight in the third eye.
Under the experimental conditions of this study, the test item was found severely irritating to the eye of rabbit. Based on these results, the test item reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda is classified Xi, R 41, risk of serious damage to eyes, according to Annex VI of the Directive 67/548/CEE and Eye Damage, Cat 1, H318 according to EU Regulation 1272/2008 (CLP), considering the persistence of eyes damages at the end of the observation period (7 days).
Reference
Result Table: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test
Unwashed right eye:
Score at time point / Reversibility |
Cornea |
Iris |
Conjunctivae |
Chemosis |
Max. score: 4 |
Max. score: 2 |
Max. score: 3 |
Max. score: 4 |
|
60 min |
2/0h/0h |
1/1/1 |
2/2/2 |
3/3/3 |
24 h |
2/0h/0h |
1/1/1 |
2/2/2 |
3/3/3 |
48 h |
2/2/2 |
1/1/1 |
3/2/2 |
3/2/3 |
72 h |
2/2/2 |
1/1/1 |
3/2/2 |
3/2/3 |
Average 24h, 48h, 72h |
2/1.33/1.33 |
1/1/1 |
2.7/2/2 |
3/2.33/3 |
Reversibility*) |
n. |
c. |
n.c. |
n. |
Average time (unit) for reversion |
- |
Day 7 |
Day 7 (2/3 eyes) |
- |
*) Reversibility: c. = completely reversible;n.c.= not completely reversible; n. = not reversible
h: lack of normal luster
Washed left eye:
Score at time point / Reversibility |
Cornea |
Iris |
Conjunctivae |
Chemosis |
Max. score: 4 |
Max. score: 2 |
Max. score: 3 |
Max. score: 4 |
|
60 min |
0/0/0 |
0/0/0 |
1/1/2 |
2/3/3 |
24 h |
0h/0h/0h |
0/1/0 |
2/2/2 |
2/3/3 |
48 h |
0h/0h/0h |
1/1/0 |
3/2/2 |
2/3/3 |
72 h |
0h/0h/0h |
1/1/0 |
3/2/2 |
2/3/3 |
Average 24h, 48h, 72h |
0/0/0 |
0.66/1/0 |
2.66/2/2 |
2/3/3 |
Reversibility*) |
n.c. (score :2 in 2 animals at day 7) |
n.c. (score :1 in 1 animal at day 7) |
n.c. (score : 1 and 2 in 2 animals at day 7) |
n.c. (score :2 in 1 animal at day 7) |
Average time (unit) for reversion |
- |
- |
- |
- |
*) Reversibility: c. = completely reversible;n.c.= not completely reversible; n. = not reversible
h: lack of normal luster
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
One Klimisch score 2 study was available for dermal irritation and was used as a key study:
In this primary dermal irritation study (1994), New Zealand Albino rabbits (3 animals) were dermally exposed to 0.5 g of undiluted test article. Intact and abraded test sites were covered with an occlusive dressing for 4 hours. Skin sites were then scored for erythema and oedema 3 min, 1 hour, 4, 24, 48, 72 hours and day 7 after patch removal. Irritation was scored by the method of Draize. In the intact skin, erythema, absent at 3 minutes post dose, was absent to slight at one and four hours. At 24 and 48 hours after patch removal, erythema was absent to well defined. At 72 hours erythema was absent to slight and absent on day 7. Edema, absent at 3 minutes post dose, was absent to slight at one and four hours. At 24 hours after patch removal, edema was absent to well defined. Edema was absent to slight at 48 hours and absent at 72 hours and on day 7. Mean scores over 24, 48 and 72 hours for each animal were 0.0, 0.33 and 1.7 for erythema and 0.0, 0.33 and 1.0 for edema. Similar effects were observed in abraded skin. The modified primary irritation index is 1.17. Under the experimental conditions of this study, the test item was slightly irritant when applied topically to rabbits.
One Klimisch score 2 study was available for eye irritation and was used as a key study:
In this primary eye irritation study (1994), 0.1 ml of test article was instilled into the conjunctival sac of each eye of New Zealand Albino rabbits (3 animals). 20-30 seconds after instillation of the test article, the left eye of each rabbit was flushed for one minute with lukewarm water. The right eye of each animal remained unwashed. Animals were then observed for 7 days. Irritation was scored by the method of Draize. For washed eyes : Corneal opacity, noted in 3/3 eyes, persisted up to day 7. Iritis, noted in 3/3 eyes, cleared by day 7. Moderate conjunctival irritation, noted in 3/3 eyes, persisted up to day 7 in one eye and improved to slight in two eyes. Mean scores calculated for each animal over 24, 48 and 72 hours were 2.0, 1.33 and 1.33 for corneal opacity; 1.0, 1.0 and 1.0 for iris lesions; 2.7, 2.0 and 2.0 for redness of the conjunctiva and 3.0, 2.33 and 3.0 for chemosis. For washed eyes: Corneal opacity was noted in two eyes on day 7. Iritis, noted in 3/3 eyes, persisted up to day 7 in one eye. Moderate conjunctival irritation, noted in 3/3 eyes, persisted up to day 7 in one eye, cleared in one eye and improved to slight in the third eye. Under the experimental conditions of this study, the test item was found severely irritating to the eye of rabbit.
Irritant effects of the respiratory tract were observed in the acute inhalation study (2013) performed in rats with an aerosol of Reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda. Indeed during the exposure and short at the end of exposure laboured, gasping and/or noisy respiration, respiratory rate increased, sneezing, were observed in the rats exposed to concentrations from 0.51 to 5.14 mg/mL for a period of 4h. During the 14 days observation period, gasping respiration, sneezing were observed in the surviving animals.
At necropsy, dark/red discoloration of the non-collapsed lungs and white foamy material in the trachea were seen in all found dead animals (n=8) receiving 5.07 and 5.14 mg/L).
The respiratory irritant effects associated with the inhalation of the registered substance were also recorded in workers exposed to the registered substance in the manufacturing plant.
Justification for selection of skin irritation / corrosion
endpoint:
Only one study available (similar to OECD 404, GLP compliant)
Justification for selection of eye irritation endpoint:
Study performed according to protocol similar to OECD 405 Guideline
(Klimisch score = 2)
Effects on eye irritation: highly irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Harmonized classification:
No harmonized classification is available according to the Regulation (EC) No 1272/2008.
Self classification:
Reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda is not classified for skin irritation according to the Regulation (EC) 1272/2008 (CLP) and to the Directive 67/548/EEC.
Reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda is classified as Eye Damage Cat. 1, H318 according to the Regulation (EC) 1272/2008 (CLP) and GHS UN, considering the persistence of eyes damages in rabbit at the end of the observation period (7 days).
Reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda is classified as STOT-SE 3, H335 according to the Regulation (EC) 1272/2008 (CLP) and GHS UN considering the irritant effects on the respiratory tract observed in the acute inhalation study in rat and the human cases reported in the manufacturing plant.
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