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EC number: 939-368-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 05 August 1997 to 10 October 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to EU / OECD guidelines and non- GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda
- EC Number:
- 939-368-0
- Cas Number:
- 1322-93-6
- Molecular formula:
- Not applicable (a generic molecular formula can not be provided for this specific UVCB substance)
- IUPAC Name:
- Reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- See confidential details on test material section
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Credo, 69210 L'Arbresle. France.
- Age at study initiation: 6 weeks old
- Weight at study initiation: 177-206 g for the males, 162-186 g for the females
- Fasting period before study: Animals are fasted the day before. They are divided into 3 groups of 10 (five of each sex).
- Housing: The animals were housed in groups of 5 animals of the same sex in polypropylene cages (310x465x190).
- Food consumption (e.g. ad libitum): ad libitum. Pelleted feed UAR A04-10 (91360 - EPINAY SUR ORGE, FRANCE)
- Water consumption (e.g. ad libitum): ad libitum
- Acclimation period: 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data available
- Humidity (%): no data available
- Air changes (per hr): no data available
- Photoperiod (hrs dark / hrs light): no data available
In-life dates: From 05 to 28 August 1997
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Details on oral exposure:
- VEHICLE
The vehicle used was distilled water (Meram lot 62421)
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg
DOSAGE PREPARATION:
The test substance is used diluted in distilled water. It is maintained under magnetic stirring for the duration of treatment.
- Doses:
- 200, 600 and 1800 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- DETAILS ON STUDY DESIGN
- Duration of observation period following administration: 14 days
- Frequency of observations: the animals were observed frequently after administration of the test substance and at least once a day for clinical signs and at least twice a day for mortality.
- Frequency of weighing: Animals were weighed just before administration of the test substance and then on days 4, 8 and 15.
- Necropsy of survivors performed: yes on day 15
- Other examinations performed: macroscopic examination at necropsy (digestive tract, heart, kidneys, liver, lungs, pancreas, spleen and any other organ with obvious abnormalities) - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 600 - < 1 800 mg/kg bw
- Based on:
- test mat.
- Mortality:
- At 200 and 600 mg/kg, no deaths occured during the observation period.
At 1800 mg/kg, one female died after 5 h, 2 males and 3 females died on day 2. - Clinical signs:
- other: No clinical signs were observed during the study in animals treated with 200 and 600 mg/kg. Piloerection, decreased motor activity, hypertension and loss of grip were noted in animals treated with 1800 mg/kg at least until the 6th hour of observation. Dur
- Gross pathology:
- The macroscopic examination of the main organs of the animals death during the test or sacrified at the end of the study revealed no apparent abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the experimental conditions of this study, the oral LD50 of the test item reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda was between 600 and 1800 mg/kg in rats.
- Executive summary:
The substance reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda has been tested for acute oral toxicity in Sprague Dawley rats, according to O.E.C.D. guideline Nb.401. The test article (76% active), diluted in distilled water, was administered as a single dose of 200, 600 and 1800 mg/kg bw to groups of 5 males and 5 females, at a dosing volume of 5 ml/kg. Following treatment, mortality, clinical signs and body weight were recorded for a two-week observation period. On day 15, the animals were euthanatized and necropsied.
At 200 and 600 mg/kg, no deaths occured during the observation period. At 1800 mg/kg, one female died after 5 h, 2 males and 3 females died on day 2.
No clinical signs were observed during the study in animals treated with 200 and 600 mg/kg. Piloerection, decreased motor activity, hypertension and loss of grip were noted in animals treated with 1800 mg/kg at least until the 6th hour of observation. During the daily examinations performed during the observation period day 2 to day 15, no impairment of general condition and behavior of surviving animals were noted.
The body weight gain of the animals was normal in animals treated with 200 and 600 mg/kg. The body weight gain of the surviving males treated with 1800 mg/kg on day 15 was slightly lower (-14%) than other doses, but their weight change was however satisfactory. The surviving female treated with 1800 mg/kg presented a slight weight loss at day 4. This weight drop was offset later, his weight gain appeared normal and satisfactory at the end of the observation.
The macroscopic examination of the main organs of the animals dead during the test or sacrified at the end of the study revealed no apparent abnormalities.
As the acute oral LD50 was found between 600 and 1800 mg/kg (456 -1368 mg/kg as active) under the conditions of the test, reaction product of naphthalene, propan-2-ol, sulfonated and neutralized by caustic soda is classified as Acute tox. 4 (H302) according to the Regulation (EC) 1272/2008 (CLP) and as harmful Xn, R22 according to the Directive 67/548/CEE.
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